Department of Cardiovascular Disease, Pulmonary Hypertension and Adult Congential Heart Disease Program, Advanced Heart Failure and Transplantation Program, The Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA.
Heart Fail Clin. 2012 Jul;8(3):403-12. doi: 10.1016/j.hfc.2012.04.005.
The right ventricle (RV) is in charge of pumping blood to the lungs for oxygenation. Pulmonary arterial hypertension (PAH) is characterized by high pulmonary vascular resistance and vascular remodeling, which results in a striking increase in RV afterload and subsequent failure. There is still unexploited potential for therapies that directly target the RV with the aim of supporting and protecting the right side of the heart, striving to prolong survival in patients with PAH.
右心室（RV）负责将血液泵送到肺部进行氧合。肺动脉高压（PAH）的特征是肺血管阻力增加和血管重构，这导致 RV 后负荷显著增加，随后发生衰竭。目前仍有未开发的治疗潜力，可以直接针对 RV 进行治疗，旨在支持和保护心脏的右侧，努力延长 PAH 患者的生存时间。
