College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
Eur J Med Chem. 2012 Aug;54:582-90. doi: 10.1016/j.ejmech.2012.06.009. Epub 2012 Jun 15.
In an attempt to develop novel anthelmintic agents, our previously isolated osthol was used as lead structures for further optimization. In our research, a series of coumarin analogs, prepared from 7-hydroxy coumarin or 7-hydroxy-4-methyl coumarin, have been evaluated for their anthelmintic activities. In all of the compounds, 6 and 7 were first synthesized, and their structures were identified based on NMR and MS values. Among the candidates, 8-allyl-7-allyloxycoumarin showed better anthelmintic activity than other compounds against Dactylogyrus infestation with EC(50) value of 1.81 mg/L. The quantitative structure-activity relationship (QSAR) of 16 osthol analogs with anthelmintic activity expressed as pEC(50) and toxicity to goldfish expressed pLC(50), such results can offer useful theoretical references for future experimental works.
为了开发新型驱虫药，我们以前分离出的蛇床子素被用作进一步优化的先导结构。在我们的研究中，我们评估了一系列香豆素类似物的驱虫活性，这些类似物是由 7-羟基香豆素或 7-羟基-4-甲基香豆素制备的。在所有化合物中，首先合成了 6 和 7，并根据 NMR 和 MS 值确定了它们的结构。在候选化合物中，8-丙烯基-7-丙烯氧基香豆素对栉虫感染的驱虫活性优于其他化合物，EC（50）值为 1.81mg/L。16 种具有驱虫活性的蛇床子素类似物的定量构效关系（QSAR）表示为 pEC（50）和对金鱼的毒性表示为 pLC（50），这些结果可为未来的实验工作提供有用的理论参考。
