Institute of Biosciences, UNESP, Univ. Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil.
Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):10-5. doi: 10.1016/j.archger.2012.06.003. Epub 2012 Jun 29.
The objective of this study was to conduct a systematic review of studies that analyzed the effect of physical exercise on the peripheral levels of BDNF in elderly individuals.
We conducted a search in PsycINFO, Biological Abstracts, Pubmed, Web of Science, and Science Direct from 1990 to 2011, using the following keywords: "physical exercise", "physical activity", "physical therapy", "training", "BDNF", "neuroplasticity", "neurotrophins", "neuroplasticity proteins", "aged", "older", "elderly". The articles were considered for inclusion in the review if they were studies with elderly, assessed peripheral (serum and/or plasma) BDNF and evaluated an acute exercise or chronic exercise (training).
Five randomized controlled trial and one randomized non-controlled trial studies were analyzed. Five out of six studies reported a significantly higher BDNF response to aerobic acute exercise and to aerobic or strength training program in healthy elderly and elderly with different pathologies.
It was not possible to establish a recommendation protocol for the type and intensity of physical exercise required to produce an increase in levels BDNF. However, physical exercise, particularly, moderate-intensity exercises seem to be more effective to promote increase the peripheral levels of BDNF in the elderly.
本研究旨在对分析老年人身体锻炼对 BDNF 外周水平影响的研究进行系统回顾。
我们在 1990 年至 2011 年间在 PsycINFO、Biological Abstracts、Pubmed、Web of Science 和 Science Direct 中使用了以下关键词进行搜索：“身体锻炼”、“体育活动”、“物理疗法”、“训练”、“BDNF”、“神经可塑性”、“神经营养因子”、“神经可塑性蛋白”、“老年人”、“老年”、“老年人”。如果研究对象为老年人，评估外周（血清和/或血浆）BDNF 并评估急性运动或慢性运动（训练），则将其纳入综述。
分析了五篇随机对照试验和一篇随机非对照试验研究。六项研究中有五项报告称，健康老年人和患有不同疾病的老年人对急性有氧运动和有氧运动或力量训练方案的 BDNF 反应更高。
尚无法确定产生 BDNF 水平升高所需的运动类型和强度的推荐方案。然而，身体锻炼，特别是中等强度的运动，似乎更能有效促进老年人外周 BDNF 水平的升高。
