Department of Surgery, Clinical Sciences Lund, Skåne University Hospital, Lund, Sweden.
Respir Med. 2012 Sep;106(9):1199-210. doi: 10.1016/j.rmed.2012.06.003. Epub 2012 Jun 29.
Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality. Underlying mechanisms are complex and poorly understood, although recent insights have identified several inflammatory profiles and cellular components involved to varying degrees during different phases of pancreatitis exacerbation and acute lung injury. This review aims to highlight the current understanding of the inflammatory and cellular components involved in and responsible for the associations of acute pancreatitis and acute lung injury, with the hope of thereby providing an increased understanding of the underlying mechanisms. In addition, novel experimental models of modulating the pancreatitis-associated acute lung injury are presented, interventions that may be of potential future clinical value.
急性肺损伤是急性胰腺炎的严重并发症，也是与相当高死亡率相关的重大健康问题。虽然最近的研究已经确定了在胰腺炎加重和急性肺损伤的不同阶段涉及的几种炎症特征和细胞成分，但潜在机制仍然很复杂且尚未被完全理解。本篇综述旨在强调目前对参与和导致急性胰腺炎与急性肺损伤相关的炎症和细胞成分的理解，以期增加对潜在机制的认识。此外，还提出了调节胰腺炎相关急性肺损伤的新型实验模型，这些干预措施可能具有潜在的临床应用价值。
