Yu Rwei-Ling, Wu Ruey-Meei
College of Medicine, Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Neurology, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Front Aging Neurosci. 2022 Sep 6;14:943438. doi: 10.3389/fnagi.2022.943438. eCollection 2022.
Mild cognitive impairment (MCI) is one of the common non-motor symptoms in patients with Parkinson's disease (PD). MCI is the transition stage between normal aging and full-blown dementia and is also a powerful predictor of dementia. Although the concept of MCI has been used to describe some of the PD symptoms for many years, there is a lack of consistent diagnostic criteria. Moreover, because of the diverse patterns of the cognitive functions, each cognitive impairment will have a different progression. In this review, we overviewed the diagnostic criteria for PD-MCI, primarily focused on the heterogeneity of PD-MCI patients' cognitive function, including various types of cognitive functions and their progression rates. A review of this topic is expected to be beneficial for clinical diagnosis, early intervention, and treatment. In addition, we also discussed the unmet needs and future vision in this field.
轻度认知障碍(MCI)是帕金森病(PD)患者常见的非运动症状之一。MCI是正常衰老与全面痴呆之间的过渡阶段,也是痴呆的有力预测指标。尽管MCI的概念多年来一直用于描述某些PD症状,但缺乏一致的诊断标准。此外,由于认知功能模式多样,每种认知障碍的进展情况会有所不同。在本综述中,我们概述了PD-MCI的诊断标准,主要关注PD-MCI患者认知功能的异质性,包括各种类型的认知功能及其进展速度。对这一主题的综述有望对临床诊断、早期干预和治疗有益。此外,我们还讨论了该领域未满足的需求和未来展望。