Department of Neurology, Medical University, Sofia, Bulgaria.
Am J Alzheimers Dis Other Demen. 2012 Dec;27(8):614-9. doi: 10.1177/1533317512460562. Epub 2012 Sep 19.
Recently, a strong interest has emerged in recognizing Parkinson's disease dementia (PDD) at a very early stage. However, the specific profile of the earliest stages of PDD is still unclear and a matter of considerable controversy. The objective of this study was to find out early neuropsychological markers for progression of dementia in this population. Fifty-eight patients with PDD were divided into 2 subgroups on the basis of the Mini-Mental State Examination: very mild and mild. The comparison with 26 normal controls shows that very mild PDD had deficits on attention/executive functions, naming, visuospatial/constructional abilities and retrieval of the episodic memory. Patients with mild PDD showed additional deficits on coding of episodic memory. Moreover, we found that in this early stage of PDD, the progression of dementia is mainly related to deterioration of attention/executive functions as well as retrieval and coding of episodic memory.
最近，人们对在极早期识别帕金森病痴呆（PDD）产生了浓厚的兴趣。然而，PDD 最早阶段的具体特征仍不清楚，存在很大争议。本研究旨在找出该人群痴呆进展的早期神经心理学标志物。根据 Mini-Mental State Examination，将 58 名 PDD 患者分为 2 个亚组：非常轻度和轻度。与 26 名正常对照的比较表明，非常轻度 PDD 在注意力/执行功能、命名、视空间/结构能力和情景记忆检索方面存在缺陷。轻度 PDD 患者在情景记忆编码方面存在额外的缺陷。此外，我们发现，在 PDD 的早期阶段，痴呆的进展主要与注意力/执行功能以及情景记忆的检索和编码的恶化有关。
