University of Kansas School of Medicine-Wichita, Department of Pediatrics, Wichita, KS 67214, United States.
Vaccine. 2012 Aug 3;30(36):5305-9. doi: 10.1016/j.vaccine.2012.06.058. Epub 2012 Jun 29.
To pilot test the Text Reminders for Immunization Compliance in Kids (TRICKs) program to evaluate its feasibility and potential to increase immunization coverage.
Randomized controlled trial (RCT).
Pediatric clinic.
Parents of newborns being discharged from a local hospital who intended to seek child health care at the University-sponsored pediatric resident and faculty clinic.
Text message immunization reminders prior to immunization due dates.
Receipt and timeliness of immunizations at 2, 4 and 6 months of age.
Participants (N=90) were English (83%) or Spanish (17%) speaking. The majority were female (83%), on public insurance (59%), and had adequate health literacy (96%). Parents were married or a member of an unmarried couple (62%). Over 66% had a high school diploma or less. Greater numbers of intervention children received immunizations and were "on time" using per protocol analysis; though not statistically significance. Limitations include sample size, problematic text messaging software, and loss of phone service at 7 months for 40% of intervention parents. However, post-intervention interviews (N=18) indicated strong support for TRICKs; 83% found the text message reminders very helpful and 17% somewhat helpful.
Pilot testing allowed us to assess processes, including recruitment, retention, and software, which will increase the success of an RCT. Software with built-in backup systems is needed for follow-up when mobile service is interrupted. However, in spite of limitations, immunization rates were higher in the text message reminder group, though not statistically significant. Parent support and interest was high. A fully powered RCT is needed with follow-up over the full 4-3-1-3-3-1 series. Based on our results, for 80% power where we expected 90% compliance in the intervention group and 80% in the control group we need 219 per group, plus increases to address drop out and loss of follow-up.
试用免疫合规文本提醒程序（TRICKs），评估其提高免疫覆盖率的可行性和潜力。
随机对照试验（RCT）。
儿科诊所。
从当地医院出院的新生儿父母，他们打算在大学赞助的儿科住院医生和教员诊所寻求儿童保健。
在免疫接种截止日期前发送免疫接种提醒短信。
2、4 和 6 个月龄时的免疫接种接受情况和及时性。
参与者（N=90）为英语（83%）或西班牙语（17%）。大多数为女性（83%），参加公共保险（59%），具有足够的健康素养（96%）。父母已婚或为未婚伴侣的一员（62%）。超过 66%的人拥有高中文凭或以下。更多的干预儿童接受了免疫接种，并且按照方案分析“按时”接种；尽管没有统计学意义。限制包括样本量、有问题的短信软件以及 7 个月时 40%的干预父母失去手机服务。然而，干预后访谈（N=18）表示强烈支持 TRICKs；83%的人认为短信提醒非常有帮助，17%的人认为有点帮助。
试点测试使我们能够评估包括招募、保留和软件在内的过程，这些过程将增加 RCT 的成功率。需要具有内置备份系统的软件，以便在移动服务中断时进行随访。然而，尽管存在限制，短信提醒组的免疫接种率较高，尽管没有统计学意义。家长的支持和兴趣很高。需要进行一项全面的、有后续随访的 RCT，覆盖完整的 4-3-1-3-3-1 系列。根据我们的结果，在我们预计干预组 90%的依从性和对照组 80%的依从性下，我们需要每组 219 名参与者，加上增加以解决脱落和随访丢失。
