短信提醒儿童接种流感疫苗第二剂：一项 RCT 研究。

Text Message Reminders for the Second Dose of Influenza Vaccine for Children: An RCT.

机构信息

Division of Child and Adolescent Health, Department of Pediatrics, Columbia University, New York, New York.

Department of Population and Family Health, Mailman School of Public Health, Columbia University, New York, New York.

出版信息

Pediatrics. 2022 Sep 1;150(3). doi: 10.1542/peds.2022-056967.

DOI:10.1542/peds.2022-056967

PMID:35965283

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9592065/

Abstract

BACKGROUND AND OBJECTIVES

Among children requiring 2 influenza doses in a given season, second dose receipt nearly halves the odds of influenza. Nationally, many children do not receive both needed doses. This study sought to compare the effectiveness of text message reminders with embedded interactive educational information versus usual care on receipt and timeliness of the second dose of influenza vaccine.

METHODS

This trial took place over the 2017 to 2018 and 2018 to 2019 influenza seasons among 50 pediatric primary care offices across 24 states primarily from the American Academy of Pediatrics' Pediatric Research in Office Settings practice-based research network. Caregiver-child dyads of children 6 months to 8 years in need of a second influenza vaccination that season were individually randomized 1:1 into intervention versus usual care, stratified by age and language within each practice. Intervention caregivers received automated, personalized text messages, including educational information. Second dose receipt by April 30 (season end) and by day 42 (2 weeks after second dose due date) were assessed using Mantel Haenszel methods by practice and language. Analyses were intention to treat.

RESULTS

Among 2086 dyads enrolled, most children were 6 to 23 months and half publicly insured. Intervention children were more likely to receive a second dose by season end (83.8% versus 80.9%; adjusted risk difference (ARD) 3.8%; 95% confidence interval [0.1 to 7.5]) and day 42 (62.4% versus 55.7%; ARD 8.3% [3.6 to 13.0]).

CONCLUSIONS

In this large-scale trial of primary care pediatric practices across the United States, text message reminders were effective in promoting increased and timelier second dose influenza vaccine receipt.

摘要

背景与目的

在一个季节内需要接种 2 剂流感疫苗的儿童中，第二剂的接种率几乎降低了一半流感感染风险。在全国范围内，许多儿童并未接种完所需的两剂疫苗。本研究旨在比较短信提醒与嵌入式互动教育信息在提高和及时接种流感疫苗第二剂方面的效果。

方法

本试验于 2017 至 2018 年和 2018 至 2019 年流感季节期间在全美 24 个州的 50 家儿科初级保健办公室进行，主要来自美国儿科学会儿科在诊间开展研究实践网络。本研究对每个季节需要接种第二剂流感疫苗的 6 个月至 8 岁儿童的照顾者-儿童二人组进行了个体随机分组，1:1 分为干预组和常规护理组，按每个诊所的年龄和语言进行分层。干预组的照顾者会收到自动个性化短信，包括教育信息。通过实践和语言进行 Mantel Haenszel 方法评估 4 月 30 日（季节结束）和 42 天（第二剂到期日后 2 周）时的第二剂接种率。分析采用意向治疗。

结果

在纳入的 2086 对二人组中，大多数儿童为 6 至 23 个月，一半有公共保险。干预组儿童在季节结束时更有可能接种第二剂疫苗（83.8%比 80.9%；调整风险差异[ARD]3.8%；95%置信区间[0.1 至 7.5]）和第 42 天（62.4%比 55.7%；ARD 8.3%[3.6 至 13.0]）。