Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Semin Cell Dev Biol. 2012 Sep;23(7):803-11. doi: 10.1016/j.semcdb.2012.06.001. Epub 2012 Jun 26.
The Hippo signaling pathway is an evolutionarily conserved mediator of growth control, cell fate decisions and stem cell identity. At the heart of the pathway is a kinase cascade that is reminiscent of other signaling pathways, but recent studies indicate that the Hippo pathway is unique in that it is regulated by cellular architecture and the mechanical properties of the environment. The Hippo pathway may thus serve as a sensor of tissue structure and mechanical tension, integrating information regarding the size and shape of an organ into cellular behavior, such as whether or not to proliferate. In this review we summarize recent discoveries regarding the regulation of the Hippo pathway by cellular polarity, cell junctions, and the cytoskeleton and discuss how these data inform the study of development and disease.
Hippo 信号通路是一种进化上保守的生长调控、细胞命运决定和干细胞特性的介质。该通路的核心是一个激酶级联反应，类似于其他信号通路，但最近的研究表明，Hippo 通路的独特之处在于它受到细胞结构和环境力学特性的调节。因此，Hippo 通路可以作为组织结构和机械张力的传感器，将有关器官大小和形状的信息整合到细胞行为中，例如是否增殖。在这篇综述中，我们总结了最近关于 Hippo 通路受细胞极性、细胞连接和细胞骨架调节的发现，并讨论了这些数据如何为发育和疾病的研究提供信息。
