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信号转导蛋白TRAP（RNAIII激活蛋白的靶点）的结构

Structure of the signal transduction protein TRAP (target of RNAIII-activating protein).

作者信息

Henrick Kim, Hirshberg Miriam

机构信息

Research Collaboratory for Structural Bioinformatics Protein Data Bank, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854-8087, USA.

出版信息

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):744-50. doi: 10.1107/S1744309112020167. Epub 2012 Jun 22.

DOI:10.1107/S1744309112020167
PMID:22750855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3388912/
Abstract

The crystal structure of the signal transduction protein TRAP is reported at 1.85 Å resolution. The structure of TRAP consists of a central eight-stranded β-barrel flanked asymmetrically by helices and is monomeric both in solution and in the crystal structure. A formate ion was found bound to TRAP identically in all four molecules in the asymmetric unit.

摘要

信号转导蛋白TRAP的晶体结构以1.85 Å的分辨率被报道。TRAP的结构由一个中央八链β桶组成，其两侧不对称地排列着螺旋，并且在溶液和晶体结构中均为单体。在不对称单元的所有四个分子中，均发现有一个甲酸根离子以相同方式与TRAP结合。

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本文引用的文献

1
Processing of X-ray diffraction data collected in oscillation mode.振荡模式下收集的X射线衍射数据的处理。
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2
The Pfam protein families database.Pfam 蛋白质家族数据库。
Nucleic Acids Res. 2012 Jan;40(Database issue):D290-301. doi: 10.1093/nar/gkr1065. Epub 2011 Nov 29.
3
KEGG for integration and interpretation of large-scale molecular data sets.KEGG 用于整合和解释大规模分子数据集。
Nucleic Acids Res. 2012 Jan;40(Database issue):D109-14. doi: 10.1093/nar/gkr988. Epub 2011 Nov 10.
4
Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases.枯草芽孢杆菌 Fur 抑制两种同源血红素降解单加氧酶之一。
Microbiology (Reading). 2011 Nov;157(Pt 11):3221-3231. doi: 10.1099/mic.0.053579-0. Epub 2011 Aug 26.
5
Vaccine development for the prevention of staphylococcal mastitis in dairy cows.用于预防奶牛葡萄球菌性乳腺炎的疫苗研发。
Vet Immunol Immunopathol. 2011 Jul 15;142(1-2):25-35. doi: 10.1016/j.vetimm.2011.03.023. Epub 2011 Apr 8.
6
REFMAC5 for the refinement of macromolecular crystal structures.用于大分子晶体结构精修的REFMAC5
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67. doi: 10.1107/S0907444911001314. Epub 2011 Mar 18.
7
YhgC protects Bacillus anthracis from oxidative stress.YhgC可保护炭疽芽孢杆菌免受氧化应激。
Int J Artif Organs. 2010 Sep;33(9):590-607.
8
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Nucleic Acids Res. 2010 Jul;38(Web Server issue):W469-73. doi: 10.1093/nar/gkq406. Epub 2010 May 31.
9
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10
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Int J Artif Organs. 2009 Sep;32(9):592-9. doi: 10.1177/039139880903200908.