体内重编程治疗心脏病。
In vivo reprogramming for heart disease.
机构信息
1] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
出版信息
Cell Res. 2012 Nov;22(11):1521-3. doi: 10.1038/cr.2012.101. Epub 2012 Jul 3.
Abstract
The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative approach for the development of cardiac therapeutics.
摘要
“谱系重编程”一词通常用于描述一种分化的体细胞类型在不经过多能中间状态的情况下转化为另一种类型。《自然》杂志最近的两项研究报告表明，这种转化可以在心脏原位实现，并为心脏治疗药物的开发提供了一种新的、有前景的再生方法。
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