诱导再生——直接重编程在心脏修复中的进展与前景。
Induced regeneration--the progress and promise of direct reprogramming for heart repair.
机构信息
Department of Cell and Developmental Biology, Institute for Regenerative Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
Nat Med. 2013 Jul;19(7):829-36. doi: 10.1038/nm.3225.
Abstract
Regeneration of cardiac tissue has the potential to transform cardiovascular medicine. Recent advances in stem cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools to advance this goal. In this Review we examine key developments in the generation of new cardiomyocytes in vitro as well as the exciting progress that has been made toward in vivo reprogramming of cardiac tissue. We also address controversies and hurdles that challenge the field.
摘要
心肌组织的再生有可能改变心血管医学。近年来，干细胞生物学和直接重编程（或转分化）的进展为推进这一目标提供了强大的新工具。在这篇综述中，我们考察了体外生成新心肌细胞的关键进展，以及在体内对心脏组织进行重编程方面所取得的令人兴奋的进展。我们还讨论了挑战该领域的争议和障碍。
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