全基因组关联研究在汉族人群中鉴定出冠心病的四个新的易感位点。
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
机构信息
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Nat Genet. 2012 Jul 1;44(8):890-4. doi: 10.1038/ng.2337.
Abstract
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
摘要
我们进行了一项荟萃分析，该分析包含了 2 项针对中国汉族人群的冠心病全基因组关联研究，共包括 1515 例病例和 5019 例对照，随后在 15460 例病例和 11472 例对照中进行了复制研究。我们确定了 4 个新的冠心病易感基因位点，这些基因位点达到了全基因组显著性阈值（P < 5×10(-8))。这些基因位点位于 TTC32-WDR35、GUCY1A3、C6orf10-BTNL2 和 ATP2B1 内或附近。我们还复制了先前在欧洲人群中发现的 4 个基因位点（位于 PHACTR1、TCF21、CDKN2A-CDKN2B 和 C12orf51 内或附近）。这些发现为中国汉族人群冠心病易感性的相关途径提供了新的见解。
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