[Indices of the functional state of the hypothalamus-hypophysis-ovaries system in women with Itsenko-Cushing disease].

The content of gonadotropic hormones, prolactin and sex steroids were examined in the blood of 97 women with Itsenko-Cushing disease before and after administration of LH-RH and chorionic gonadotropin hormone. It was found that women with Itsenko-Cushing disease revealed a reduced concentration of gonadotropic hormones while the level of testosterone, progesterone, prolactin was increased. Estradiol remained unchanged. LH-RH tests indicate that women with Itsenko-Cushing disease revealed an abnormal synthesis and release of gonadotropins as well as secretion of LH-RH by the hypothalamus. The chorionic gonadotropin hormone test confirmed maintenance of the ovarian function.