Pedersen Marianne G, Mortensen Preben Bo, Norgaard-Pedersen Bent, Postolache Teodor T
Department of Economics and Business, National Centre for Register-Based Research, Aarhus University, Denmark.
Arch Gen Psychiatry. 2012 Nov;69(11):1123-30. doi: 10.1001/archgenpsychiatry.2012.668.
Two studies based on clinical samples have found an association between Toxoplasma gondii infection and history of suicide attempt. To our knowledge, these findings have never been replicated in a prospective cohort study.
To examine whether T gondii–infected mothers have an increased risk of self-directed violence, violent suicide attempts, and suicide and whether the risk depends on the level of T gondii IgG antibodies.
Register-based prospective cohort study. Women were followed up from the date of delivery, 1992 to 1995 until 2006.
Denmark.
A cohort of 45 788 women born in Denmark whose level of Toxoplasma-specific IgG antibodies was measured in connection with child birth between 1992 and 1995.
Incidence rates of self-directed violence, violent suicide attempts, and suicide in relation to T gondii seropositivity and serointensity.
T gondii–infected mothers had a relative risk of self-directed violence of 1.53 (95% CI, 1.27-1.85) compared with noninfected mothers, and the risk seemed to increase with increasing IgG antibody level. For violent suicide attempts, the relative risk was 1.81 (95% CI, 1.13-2.84) and for suicide, 2.05 (95% CI, 0.78-5.20). A similar association was found for repetition of self-directed violence, with a relative risk of 1.54 (95% CI, 0.98-2.39).
Women with a T gondii infection have an increased risk of self-directed violence.
两项基于临床样本的研究发现弓形虫感染与自杀未遂史之间存在关联。据我们所知，这些发现从未在前瞻性队列研究中得到重复验证。
研究感染弓形虫的母亲发生自我导向暴力、暴力自杀未遂和自杀的风险是否增加，以及该风险是否取决于弓形虫IgG抗体水平。
基于登记的前瞻性队列研究。对1992年至1995年分娩的女性进行随访，直至2006年。
丹麦。
丹麦出生的45788名女性队列，她们在1992年至1995年分娩时检测了弓形虫特异性IgG抗体水平。
与弓形虫血清阳性和血清强度相关的自我导向暴力、暴力自杀未遂和自杀的发病率。
与未感染的母亲相比，感染弓形虫的母亲发生自我导向暴力的相对风险为1.53（95%可信区间，1.27 - 1.85），且风险似乎随着IgG抗体水平的升高而增加。对于暴力自杀未遂，相对风险为1.81（95%可信区间，1.13 - 2.84），对于自杀，相对风险为2.05（95%可信区间，0.78 - 5.20）。在自我导向暴力的复发方面也发现了类似的关联，相对风险为1.54（95%可信区间，0.98 - 2.39）。
感染弓形虫的女性发生自我导向暴力的风险增加。
