National Center for Register-Based Research, Aarhus University, Denmark.
Am J Psychiatry. 2011 Aug;168(8):814-21. doi: 10.1176/appi.ajp.2011.10091351. Epub 2011 May 2.
Several studies based on clinical samples have found an association between Toxoplasma gondii infection and schizophrenia, and a case-control study among U.S. military personnel with specimens available from both before and after diagnosis found a positive association between T. gondii immunoglobulin G (IgG) antibody level and schizophrenia. These findings have never been replicated in a prospective cohort study. The purpose of this study was to determine whether mothers infected with T. gondii have an elevated risk of schizophrenia or related disorders and whether the risk depends on IgG antibody level.
In a register-based prospective cohort study of 45,609 women born in Denmark, the level of T. gondii-specific IgG antibodies was measured in connection with childbirth between 1992 and 1995. Women were followed up from the date of delivery until 2008.
A significant positive association between T. gondii IgG antibody level and schizophrenia spectrum disorders was found. Mothers with the highest IgG level had a relative risk of 1.73 (95% confidence interval [CI]=1.12-2.62) compared with mothers with the lowest IgG level. For schizophrenia, the relative risk was 1.68 (95% CI=0.77-3.46). When the mothers were classified according to IgG level, only those with the highest IgG levels had a significantly higher risk of schizophrenia spectrum disorders.
Women with high levels of T. gondii-specific IgG antibodies have a significantly elevated risk of developing schizophrenia spectrum disorders.
几项基于临床样本的研究发现，弓形虫感染与精神分裂症之间存在关联，而一项针对美国军事人员的病例对照研究发现，在有诊断前后标本的情况下，弓形虫免疫球蛋白 G（IgG）抗体水平与精神分裂症之间存在正相关。这些发现从未在前瞻性队列研究中得到复制。本研究的目的是确定感染弓形虫的母亲是否患有精神分裂症或相关疾病的风险增加，以及风险是否取决于 IgG 抗体水平。
在一项基于登记的前瞻性队列研究中，研究人员对 1992 年至 1995 年期间在丹麦出生的 45609 名女性进行了研究，在分娩期间测量了弓形虫特异性 IgG 抗体水平。这些女性从分娩日期开始随访，直到 2008 年。
研究发现，弓形虫 IgG 抗体水平与精神分裂症谱系障碍之间存在显著正相关。与 IgG 水平最低的母亲相比，IgG 水平最高的母亲患精神分裂症谱系障碍的相对风险为 1.73（95%置信区间[CI]=1.12-2.62）。对于精神分裂症，相对风险为 1.68（95% CI=0.77-3.46）。当根据 IgG 水平对母亲进行分类时，只有 IgG 水平最高的母亲患精神分裂症谱系障碍的风险显著升高。
弓形虫特异性 IgG 抗体水平较高的女性患精神分裂症谱系障碍的风险显著升高。
