Department of Radiology, Breast Imaging Section, Memorial Sloan-Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA.
Eur Radiol. 2012 Dec;22(12):2641-7. doi: 10.1007/s00330-012-2553-8. Epub 2012 Jul 4.
To evaluate the effect of menopausal status on the background parenchymal enhancement (BPE) and amount of fibroglandular tissue (FGT) on breast MRI.
Retrospective review identified 1,130 women who underwent screening breast MRI between July and November 2010. In 28 of these women, breast MRI was performed both at one time point while pre- and one time point while post-menopausal (median interval 49 months). Two independent readers blinded to menopausal status used categorical scales to rate BPE (minimal/mild/moderate/marked) and FGT (fatty/scattered/heterogeneously dense/dense). Consensus was reached when there was disagreement. The sign test was used to assess changes in rating categories, and the Spearman rank and Fisher's exact tests were used to measure correlations and associations between variables.
Significant proportions of women demonstrated decreases in BPE and FGT on post-menopausal breast MRI (P = 0.0001 and P = 0.0009). BPE category was unchanged in 39 % (11/28) and decreased in 61 % (17/28) of women. FGT category was unchanged in 61 % (17/28) and decreased in 39 % (11/28) of women. Age, reason for menopause, or interval between MRIs had no significant impact on changes in BPE and FGT.
On MRI, BPE, and FGT decrease after menopause in significant proportions of women; BPE decreases more than FGT.
On MRI, background parenchymal enhancement and fibroglandular tissue both decrease after menopause. The reduced postmenopausal enhancement is more marked in parenchyma than fibroglandular tissue. Background enhancement and fibroglandular tissue seen on MRI are under hormonal influence.
评估绝经状态对乳腺 MRI 背景实质强化（BPE）和纤维腺体组织（FGT）量的影响。
回顾性分析 2010 年 7 月至 11 月期间行乳腺 MRI 筛查的 1130 名女性。其中 28 名女性在同一时间点进行了绝经前和绝经后（中位间隔 49 个月）的乳腺 MRI 检查。两名独立的、对绝经状态不知情的读者使用分类量表对 BPE（轻度/中度/重度/明显）和 FGT（脂肪/散在/不均匀致密/致密）进行评分。当存在分歧时达成共识。使用符号检验评估评分类别的变化，使用 Spearman 秩和检验和 Fisher 精确检验测量变量之间的相关性和关联。
绝经后乳腺 MRI 显示 BPE 和 FGT 显著减少（P=0.0001 和 P=0.0009）。BPE 分类在 39%（11/28）的女性中无变化，在 61%（17/28）的女性中减少。FGT 分类在 61%（17/28）的女性中无变化，在 39%（11/28）的女性中减少。年龄、绝经原因或 MRI 之间的间隔对 BPE 和 FGT 的变化没有显著影响。
在 MRI 上，绝经后相当一部分女性的 BPE 和 FGT 减少；BPE 减少的程度大于 FGT。
在 MRI 上，背景实质强化和纤维腺体组织在绝经后都减少。绝经后增强的减少在实质中比纤维腺体组织更为明显。MRI 上看到的背景增强和纤维腺体组织受激素影响。
