Department of Radiology, The University of Chicago, 5841 South Maryland Avenue, MC 2026, Chicago, IL 60637, USA.
Eur Radiol. 2011 Jul;21(7):1374-82. doi: 10.1007/s00330-011-2080-z. Epub 2011 Feb 17.
To characterize the kinetic and morphological presentation of normal breast tissue on DCE-MRI in a large cohort of asymptomatic women, and to relate these characteristics to breast tissue density.
335 consecutive breast MR examinations in 229 asymptomatic women undergoing high-risk screening evaluations based on recommendations from the American Cancer Society including strong family history and genetic predisposition were selected for IRB-approved review (average age 49.2 ± 10.5 years). Breast tissue density was assessed on precontrast T₂-weighted images. Parenchymal enhancement pattern (PEP) was qualitatively classified as minimal, homogeneous, heterogeneous or nodular. Quantitative analysis of parenchymal enhancement kinetics (PEK) was performed, including calculation of initial and peak enhancement percentages (E₁, E(peak)), the time to peak enhancement (T ( peak )) and the signal enhancement ratio (SER).
41.8% of examinations were classified as minimal, 13.7% homogeneous, 23.9% heterogeneous and 21.2% nodular PEP. Women with heterogeneously or extremely dense breasts exhibited a higher proportion of nodular PEP (44.2% (27/61)) and significantly higher E₁, and E(peak) (p < 0.003) compared with those with less dense breasts.
Qualitative and quantitative parenchymal enhancement characteristics vary by breast tissue density. In future work, the association between image-derived MR features of the normal breast and breast cancer risk should be explored.
在一个大型无症状女性队列中，描述 DCE-MRI 上正常乳腺组织的动力学和形态学表现，并将这些特征与乳腺组织密度相关联。
选择了 229 名无症状妇女的 335 次连续乳腺磁共振检查，这些妇女是根据美国癌症协会的建议进行高风险筛查评估的，包括强烈的家族史和遗传倾向（平均年龄 49.2±10.5 岁）。在对比前 T₂加权图像上评估乳腺组织密度。实质增强模式（PEP）定性分类为最小、均匀、不均匀或结节状。对实质增强动力学（PEK）进行定量分析，包括计算初始和峰值增强百分比（E₁、E（peak））、达到峰值增强的时间（T（peak））和信号增强比（SER）。
41.8%的检查被分类为最小、13.7%均匀、23.9%不均匀和 21.2%结节状 PEP。乳腺不均匀或致密的妇女中，结节状 PEP 的比例更高（44.2%（27/61）），且 E₁和 E（peak）明显更高（p<0.003），与乳腺密度较低的妇女相比。
乳腺实质的增强特征在定性和定量方面均存在差异。在未来的工作中，应探讨正常乳腺的图像衍生 MRI 特征与乳腺癌风险之间的关系。
