Shamsiev S Sh, Krylov V I, Shamsiev F S
Vestn Akad Med Nauk SSSR. 1990(8):16-8.
It has been found that a most important mechanism underlying the development of various pathological conditions in the organism of neonates with perinatal hypoxic lesions of the central nervous system is the structural and functional disorganization of the cell membranes. This is associated with activation of lipid peroxidation, effect of lysosomal enzymes, and impairment of antioxidative defense. As a result, the membrane content of most important lipids is changed, their degenerative forms appear, lipoperoxides accumulate, and the activity of the membrane enzymes is inhibited. The obtained evidence serves the basis for a wide-scale application of the membranotrophic therapy for hypoxic CNS lesions in the neonates.
业已发现，患有围产期中枢神经系统缺氧性损伤的新生儿机体出现各种病理状况的一个最重要机制是细胞膜的结构和功能紊乱。这与脂质过氧化的激活、溶酶体酶的作用以及抗氧化防御功能的损害有关。结果，最重要脂质的膜含量发生变化，出现其退化形式，脂过氧化物积累，膜酶活性受到抑制。所获得的证据为膜营养疗法广泛应用于新生儿缺氧性中枢神经系统损伤提供了依据。
