Puko V M, Drozd Iu V
Farmakol Toksikol. 1990 Sep-Oct;53(5):47-8.
The purpose of the work was to study the mechanism responsible for adaptive reorganization of membranes--lipid peroxidation during simulated motion sickness (MS) in animals. It was shown that during MS rats exhibited an elevation of the level of diene conjugates and Schiff foundations in the brain indicating lipid peroxidation activation. A similar increase of phospholipase A2 activity in the brain was noted. In the liver, myocardium and erythrocytes the above changes were insignificant. An antioxidant beta-tocopherol inhibited lipid peroxidation in the rat brain and possessed the vestibule-protective effect in cats that was presumably related to its membrane-stabilizing action.
这项工作的目的是研究动物模拟晕动病（MS）期间负责膜适应性重组的机制——脂质过氧化。结果表明，在MS期间，大鼠大脑中二烯共轭物和席夫碱水平升高，表明脂质过氧化激活。同时还发现大脑中磷脂酶A2活性有类似增加。而在肝脏、心肌和红细胞中，上述变化不明显。抗氧化剂β-生育酚可抑制大鼠大脑中的脂质过氧化，并对猫具有前庭保护作用，这可能与其膜稳定作用有关。
