嗜异性抗体导致的心肌肌钙蛋白假阳性升高：是否比我们认为的更常见？
False positive cardiac troponin elevation due to heterophile antibodies: more common than we recognise?
作者信息
Zaidi Abbas, Cowell Richard
机构信息
Department of Cardiology, Singleton Hospital, Swansea, UK.
出版信息
BMJ Case Rep. 2010 Jul 15;2010:bcr1120092477. doi: 10.1136/bcr.11.2009.2477.
Abstract
A 53-year-old woman was admitted with non-exertional chest pain and elevated cardiac troponin I (cTnI) without dynamic changes of ischaemia on the ECG. She had recently undergone coronary angiography which had shown normal coronary vessels. Repeat angiography on this admission was again unremarkable. Samples of blood were sent for analysis using different troponin assays and demonstrated chronic basal elevation of cTnI while simultaneous assay for troponin T (cTnT) remained normal. Subsequent testing revealed the presence of heterophile antibodies interfering with the troponin I assay leading to a false positive result.
摘要
一名53岁女性因非劳力性胸痛和心肌肌钙蛋白I（cTnI）升高入院，心电图上无缺血的动态变化。她最近接受了冠状动脉造影，结果显示冠状动脉血管正常。此次入院复查造影结果仍无异常。采集血样使用不同的肌钙蛋白检测方法进行分析，结果显示cTnI呈慢性基础升高，而同时检测的肌钙蛋白T（cTnT）仍正常。后续检测发现存在嗜异性抗体干扰肌钙蛋白I检测，导致假阳性结果。
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