Eriksson L, Westermark P
Department of Pathology, University of Uppsala, Sweden.
Acta Neuropathol. 1990;80(6):597-603. doi: 10.1007/BF00307626.
Intracellular inclusions with staining properties of amyloid are very common in the aging choroid plexus epithelial cells. In many ways these inclusions show similarities with the neurofibrillary tangles, found in cerebral cortical neurons in patients with Alzheimer's dementia. We have now designed a purification method for choroid plexus amyloid and performed a transmission and scanning electron microscopic study. This shows that one form of choroid plexus inclusions, the Biondi ring, is a homogeneous globule covered with a thin layer of amyloid fibrils. Partial immunochemical characterization of the choroid plexus amyloid reveals that it is different from the neurofibrillary tangles although there are similarities.
具有淀粉样蛋白染色特性的细胞内包涵体在衰老的脉络丛上皮细胞中非常常见。在许多方面，这些包涵体与阿尔茨海默病痴呆患者大脑皮质神经元中发现的神经原纤维缠结相似。我们现在设计了一种脉络丛淀粉样蛋白的纯化方法，并进行了透射和扫描电子显微镜研究。结果表明，脉络丛包涵体的一种形式，即比昂迪环，是一个均匀的球体，表面覆盖着一层薄薄的淀粉样纤维。脉络丛淀粉样蛋白的部分免疫化学特征表明，尽管存在相似之处，但它与神经原纤维缠结不同。
