Department of Psychology, University of California, Los Angeles, California, USA.
Psychosom Med. 2012 Jul-Aug;74(6):665-6. doi: 10.1097/PSY.0b013e31825fe211. Epub 2012 Jun 28.
Caloric restriction is a major component of most life-style interventions. Beyond its use as an intervention tool, caloric restriction can also serve as a scientific model to study important research questions. Caloric restriction in nonhuman animals can dramatically extend the life span, and this can also be tested in humans. In addition to conducting randomized controlled trials of caloric restriction, there is much knowledge to be gained by studying already existing conditions of very long-term caloric restriction. The Cronies, members from the Calorie Restriction Society, are one such model. In addition to studying biological markers relevant to aging in the Cronies, we can also study them to understand what makes them so successful at long-term eating behavior change. This information is invaluable given the difficulties people from the general population face in adhering to calorie reduction interventions.
热量限制是大多数生活方式干预的主要组成部分。除了作为干预工具的用途外，热量限制还可以作为研究重要研究问题的科学模型。在非人类动物中进行热量限制可以显著延长寿命，这也可以在人类中进行测试。除了进行热量限制的随机对照试验外，通过研究长期热量限制的已有条件，还可以获得更多知识。Cronies 是卡路里限制协会的成员，就是这样的一个模型。除了研究 Cronies 中与衰老相关的生物标志物外，我们还可以研究它们，以了解是什么使它们在长期饮食行为改变方面如此成功。鉴于一般人群在坚持减少卡路里干预方面所面临的困难，这些信息是非常宝贵的。
