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苏格兰急诊科成人严重脓毒症和脓毒性休克的流行病学。

The epidemiology of adults with severe sepsis and septic shock in Scottish emergency departments.

机构信息

Emergency Department, Royal Infirmary of Edinburgh, Edinburgh, UK.

出版信息

Emerg Med J. 2013 May;30(5):397-401. doi: 10.1136/emermed-2012-201361. Epub 2012 Jun 29.

Abstract

BACKGROUND

The Surviving Sepsis Campaign (SSC) promotes a bundle approach to the care of septic patients to improve outcome. Some have questioned the capability of delivering the bundle in emergency departments (EDs). The authors report the epidemiology and 6 h bundle compliance of patients with severe sepsis/septic shock presenting to Scottish EDs.

METHODS

Analysis of the previously reported Scottish Trauma Audit Group sepsis database was performed including 20 mainland Scottish EDs. A total of 308,910 attendances were screened (between 2 March and 31 May 2009), and 5285 of 27,046 patients were identified after case note review and included on the database. This analysis includes patients who had severe sepsis/septic shock before leaving the ED. Epidemiological, severity of illness criteria, and ED management data were analysed.

RESULTS

626 patients (median age 73; M/F ratio 1:1; 637 presentations) met entrance criteria. The median number of cases per site was 16 (range 3-103). 561 (88.1%) patients arrived by ambulance. The most common source of infection was the respiratory tract (n=411, 64.5%) The most common physiological derangements were heart rate (n=523, 82.1%), respiratory rate (n=452, 71%) and white cell count (n=432, 67.8%). The median hospital stay was 9 days (IQR 4-17 days). 201 (31.6%) patients were admitted to critical care within 2 days, 130 (20.4%) directly from the ED. 180 patients (28.3%) died. There was poor compliance with all aspect of the SSC resuscitation bundle.

CONCLUSIONS

Sepsis presentations are of variable frequency but have typical epidemiology and clinical outcomes. SSC bundle resuscitation uptake is poor in Scottish EDs.

摘要

背景

拯救脓毒症运动(SSC)提倡采用捆绑式方法来治疗脓毒症患者,以改善预后。有人质疑在急诊科(ED)实施捆绑式治疗的能力。作者报告了苏格兰 ED 收治的严重脓毒症/脓毒性休克患者的流行病学和 6 小时捆绑式治疗依从性。

方法

对先前报道的苏格兰创伤审核组脓毒症数据库进行了分析,纳入了 20 家苏格兰大陆的 ED。共筛查了 308910 例就诊者(2009 年 3 月 2 日至 5 月 31 日),经过病历回顾,确定了 27046 例患者中的 5285 例符合纳入数据库的标准。该分析包括离开 ED 前患有严重脓毒症/脓毒性休克的患者。对流行病学、疾病严重程度标准和 ED 管理数据进行了分析。

结果

符合纳入标准的患者有 626 例(中位年龄 73 岁;男女比例 1:1;637 例就诊)。每个地点的中位病例数为 16 例(范围 3-103 例)。561 例(88.1%)患者通过救护车到达。最常见的感染源是呼吸道(n=411,64.5%)。最常见的生理紊乱是心率(n=523,82.1%)、呼吸频率(n=452,71%)和白细胞计数(n=432,67.8%)。中位住院时间为 9 天(IQR 4-17 天)。201 例(31.6%)患者在 2 天内入住重症监护病房,130 例(20.4%)直接从 ED 转入。180 例(28.3%)患者死亡。SSC 复苏捆绑治疗的所有方面依从性均较差。

结论

脓毒症就诊的频率不同,但具有典型的流行病学和临床结局。苏格兰 ED 中 SSC 捆绑式复苏治疗的接受率较低。

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