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Intensive Care Med. 2013 Apr;39(4):754-63. doi: 10.1007/s00134-012-2798-3. Epub 2013 Jan 8.
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Biomarkers: diagnosis and risk assessment in sepsis.生物标志物:脓毒症的诊断与风险评估
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Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study.血清可溶性髓系细胞触发受体-1(sTREM-1)的动态变化反映脓毒症的严重程度,并可预测预后:一项前瞻性研究。
BMC Infect Dis. 2011 Mar 1;11:53. doi: 10.1186/1471-2334-11-53.
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Rapid diagnosis of sepsis.快速诊断脓毒症。
Virulence. 2014 Jan 1;5(1):154-60. doi: 10.4161/viru.27393. Epub 2013 Dec 11.
10
Combination biomarkers to diagnose sepsis in the critically ill patient.联合生物标志物诊断危重症患者脓毒症。
Am J Respir Crit Care Med. 2012 Jul 1;186(1):65-71. doi: 10.1164/rccm.201201-0037OC. Epub 2012 Apr 26.

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Thymoquinone modulates the expression of sepsis-related microRNAs in a CLP model.百里醌在盲肠结扎穿孔模型中调节脓毒症相关微小RNA的表达。
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Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care.入住重症监护病房的严重脓毒症患者的游离循环DNA水平可预测28天死亡率。
PLoS One. 2014 Jun 23;9(6):e100514. doi: 10.1371/journal.pone.0100514. eCollection 2014.
3
Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.白细胞介素-27作为重症成年脓毒症诊断生物标志物的性能
J Crit Care. 2014 Oct;29(5):718-22. doi: 10.1016/j.jcrc.2014.04.004. Epub 2014 Apr 18.
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Metabolomic derangements are associated with mortality in critically ill adult patients.代谢紊乱与危重症成年患者的死亡率相关。
PLoS One. 2014 Jan 30;9(1):e87538. doi: 10.1371/journal.pone.0087538. eCollection 2014.
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Antibiotic prescription for respiratory tract infections in ventilated patients: where are we heading?机械通气患者呼吸道感染的抗生素处方:我们正走向何方?
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本文引用的文献

1
Combination biomarkers to diagnose sepsis in the critically ill patient.联合生物标志物诊断危重症患者脓毒症。
Am J Respir Crit Care Med. 2012 Jul 1;186(1):65-71. doi: 10.1164/rccm.201201-0037OC. Epub 2012 Apr 26.
2
The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients.中性粒细胞 CD64 表达作为生物标志物对危重症患者细菌感染的敏感性较低。
Intensive Care Med. 2012 Mar;38(3):445-52. doi: 10.1007/s00134-012-2483-6. Epub 2012 Feb 4.
3
Prostate-cancer screening--what the U.S. Preventive Services Task Force left out.前列腺癌筛查——美国预防服务工作组遗漏了什么。
N Engl J Med. 2011 Nov 24;365(21):1949-51. doi: 10.1056/NEJMp1112191. Epub 2011 Oct 26.
4
Diagnostic accuracy of HMGB-1, sTREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department.HMGB-1、sTREM-1 和 CD64 作为急诊近期收治患者脓毒症标志物的诊断准确性。
Acad Emerg Med. 2011 Aug;18(8):807-15. doi: 10.1111/j.1553-2712.2011.01113.x. Epub 2011 Jul 18.
5
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial.降钙素原指导抗感染治疗以增加早期适当使用抗生素并改善重症监护病房患者的生存率:一项随机试验。
Crit Care Med. 2011 Sep;39(9):2048-58. doi: 10.1097/CCM.0b013e31821e8791.
6
Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome.可溶性髓系细胞触发受体-1 对全身炎症反应综合征危重症患者感染的诊断准确性。
Clin Biochem. 2010 Jun;43(9):720-4. doi: 10.1016/j.clinbiochem.2010.03.001. Epub 2010 Mar 17.
7
Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial.降钙素原在 ICU 减少患者抗生素暴露的应用(PRORATA 试验):一项多中心随机对照试验。
Lancet. 2010 Feb 6;375(9713):463-74. doi: 10.1016/S0140-6736(09)61879-1. Epub 2010 Jan 25.
8
Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker.新生儿脓毒症的血液学特征:中性粒细胞CD64作为一种诊断标志物。
Pediatrics. 2008 Jan;121(1):129-34. doi: 10.1542/peds.2007-1308.
9
Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial.使用降钙素原缩短脓毒症患者抗生素治疗疗程:一项随机试验。
Am J Respir Crit Care Med. 2008 Mar 1;177(5):498-505. doi: 10.1164/rccm.200708-1238OC. Epub 2007 Dec 20.
10
Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study.联合使用血浆C反应蛋白、降钙素原、中性粒细胞、巨噬细胞移动抑制因子、可溶性尿激酶型纤溶酶原激活物受体及髓系细胞表面表达的可溶性触发受体-1诊断感染:一项前瞻性研究
Crit Care. 2007;11(2):R38. doi: 10.1186/cc5723.

The search for diagnostic markers in sepsis: many miles yet to go.

作者信息

Calfee Carolyn S, Pugin Jérôme

出版信息

Am J Respir Crit Care Med. 2012 Jul 1;186(1):2-4. doi: 10.1164/rccm.201205-0854ED.

DOI:10.1164/rccm.201205-0854ED
PMID:22753680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3400993/
Abstract
摘要