特发性肾病综合征患儿的细胞因子基因多态性
Cytokine gene polymorphism in idiopathic nephrotic syndrome children.
作者信息
Jafar Tabrez, Agrawal Suraksha, Mahdi Abbas Ali, Sharma Raj Kumar, Awasthi Shally, Agarwal G G
出版信息
Indian J Clin Biochem. 2011 Jul;26(3):296-302. doi: 10.1007/s12291-011-0126-2. Epub 2011 Apr 7.
The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-α cytokines were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction and restriction fragment length polymorphism. On comparing patient with controls strong association were found for IL-6, TNF-α and IL-4 at allelic level (IL-6-G174C (G vs. C): P = <0.001; OR = 6.33, TNF-α-G308A (G vs. A): P = <0.001; OR = 1.99, IL-4-C590T (C vs. T): P = 0.048; OR = 1.38). Further when SR group was compared with SS group significant association was found at genotypic level in all the studied genetic polymorphisms. Studied cytokine gene polymorphisms may influence susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients.
特发性肾病综合征的发病机制尚未完全明确。我们推测细胞因子基因多态性可能会影响特发性肾病综合征的易感性或临床病程。采用聚合酶链反应和限制性片段长度多态性方法，对150例特发性肾病综合征患儿和569例健康对照者的白细胞介素-4（IL-4）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）细胞因子多态性进行了研究。在等位基因水平上，将患者与对照者进行比较时，发现IL-6、TNF-α和IL-4存在强关联（IL-6-G174C（G对C）：P = <0.001；OR = 6.33，TNF-α-G308A（G对A）：P = <0.001；OR = 1.99，IL-4-C590T（C对T）：P = 0.048；OR = 1.38）。进一步将SR组与SS组进行比较时，在所有研究的基因多态性的基因型水平上均发现了显著关联。所研究的细胞因子基因多态性可能会影响特发性肾病综合征的易感性，并可能影响特发性肾病综合征患者的类固醇反应。
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