Brouwer Michael S M, Roberts Adam P, Mullany Peter, Allan Elaine
Department of Microbial Diseases; UCL Eastman Dental Institute; University College London; London, UK.
Mob Genet Elements. 2012 Jan 1;2(1):8-12. doi: 10.4161/mge.19297.
The human gut pathogen Clostridium difficile contains many conjugative transposons that have an array of accessory genes. In the current study, recently sequenced genomes were analyzed to identify new putative conjugative transposons. Eleven new elements in 5 C. difficile strains were identified and all had a similar structure to the previously described elements CTn1, CTn5 and CTn7 in C. difficile strain 630. Each element identified did however contain a new set of accessory genes compared with those previously reported; including those predicted to encode ABC transporters, a toxin/antitoxin system and multiple antibiotic resistance genes.
人类肠道病原体艰难梭菌含有许多带有一系列辅助基因的接合转座子。在当前研究中，对最近测序的基因组进行了分析，以鉴定新的假定接合转座子。在5株艰难梭菌菌株中鉴定出11个新元件，它们的结构都与艰难梭菌630菌株中先前描述的元件CTn1、CTn5和CTn7相似。然而，与先前报道的元件相比，每个鉴定出的元件都包含一组新的辅助基因；包括那些预测编码ABC转运蛋白、毒素/抗毒素系统和多个抗生素抗性基因的基因。
