远隔效应但却是理想的：免疫反应对放射治疗疗效的贡献。
Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy.
机构信息
INSERM; U848l; Villejuif, France ; Metabolomics Platform; Institut Gustave Roussy; Villejuif, France ; Centre de Recherche des Cordeliers; Paris, France ; Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP; Paris, France ; Université Paris Descartes; Faculté de Médecine; Paris, France.
出版信息
Oncoimmunology. 2012 Jul 1;1(4):407-408. doi: 10.4161/onci.20074.
Abstract
Radiotherapy applies ionizing irradiation to selected areas of the body with the scope of destroying cancer cells, either as part of curative therapies to remove a primary malignant tumor and to prevent tumor recurrence after surgery, or as part of palliative measures to avoid local advancement of bone and brain metastases. Intriguingly, radiotherapy does not only have local effects but may lead to the delayed regression of distant non-irradiated lesions. Most likely, these "abscopal" effects are mediated by the immune system.
摘要
放射疗法通过对身体选定区域进行电离辐射，来摧毁癌细胞。这种疗法既可以作为治愈疗法的一部分，用于消除原发性恶性肿瘤并防止手术后肿瘤复发，也可以作为姑息治疗的一部分，以避免骨和脑转移灶的局部进展。有趣的是，放射疗法不仅具有局部作用，而且可能导致远处未接受照射的病变的延迟消退。很可能，这些“远隔效应”是由免疫系统介导的。
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