Singh Tilakraj, Lade Himani, Natesh V
Department of ENT, VMMC and Safdarjung Hospital, Delhi, 29 India.
Indian J Otolaryngol Head Neck Surg. 2011 Jul;63(3):249-54. doi: 10.1007/s12070-011-0145-6. Epub 2011 Feb 23.
To evaluate the role of Mitomycin-C in preventing synaechiae formation and ostial stenosis following endoscopic sinus surgery. This prospective study was conducted in VMMC and Safdarjung hospital from November 2007 to August 2008. 30 subjects aged between 16 and 60 of either sex in two groups were included in the study. All these patients with bilateral nasal polyposis underwent endoscopic sinus surgery with topical application of Mitomycin-C and were subjectively and objectively assessed for improvement of symptoms and post operative synaechiae formation. Patients showed improvement in subjective symptoms mainly nasal obstruction and hyposmia as well as decreased incidence of synaechiae formation and ostial stenosis post surgery following Mitomycin-C application. After doing this study we could conclude that Mitomycin-C applied topically following endoscopic sinus surgery was helpful in improvement of symptoms like nasal obstruction and hyposmia as well as decreased adhesion rate and middle meatal antrostomy closure rate. Topical application of Motomycin-C was safe in a dose of 0.4-0.8 mg/ml applied over 5 min and offered significant improvement both subjectively and objectively.
评估丝裂霉素-C在内镜鼻窦手术后预防粘连形成和窦口狭窄中的作用。这项前瞻性研究于2007年11月至2008年8月在VMMC和萨夫达容医院进行。研究纳入了两组年龄在16至60岁之间的30名男女受试者。所有这些双侧鼻息肉患者均接受了内镜鼻窦手术，并局部应用丝裂霉素-C，对症状改善情况及术后粘连形成进行了主观和客观评估。应用丝裂霉素-C后，患者的主观症状主要是鼻塞和嗅觉减退得到改善，术后粘连形成和窦口狭窄的发生率也降低。通过这项研究我们可以得出结论，内镜鼻窦手术后局部应用丝裂霉素-C有助于改善鼻塞和嗅觉减退等症状，降低粘连率和中鼻道上颌窦造口闭合率。局部应用0.4-0.8毫克/毫升剂量的丝裂霉素-C，持续5分钟是安全的，并且在主观和客观方面均有显著改善。
