Haruyama Takuo, Furukawa Masayuki, Matsumoto Fumihiko, Abe Keiko, Arakawa Atsushi, Ikeda Katsuhisa
School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
Indian J Otolaryngol Head Neck Surg. 2011 Jul;63(Suppl 1):131-4. doi: 10.1007/s12070-011-0196-8. Epub 2011 Apr 2.
Clear cell carcinoma is rarely found in the salivary gland. It is classified as a low-grade carcinoma. This case demonstrates a low-grade clear cell carcinoma with myoepithelial features in the submandibular gland which differs from hyalinizing clear cell carcinoma and epithelial-myoepithelial carcinoma. A 32-year-old man presented with a 7 month history of left submandibular swelling. Left submandibular gland excision and left-sided supra-omohyoid neck dissection were performed. Microscopically, the tumor was circumscribed and composed predominantly of cords and nests of clear ovoid cells, set in a densely hyalinizing stroma. These cells are diffusely immunoreactive for cytokeratin AE1/AE3 and focally reactive for vimentin and smooth muscle actin (SMA). Based on these findings, the tumor was diagnosed as "a low-grade clear cell carcinoma with myoepithelial features". The post-operative course was uneventful and the patient is free from disease 21 month after surgery.
透明细胞癌在涎腺中罕见。它被归类为低级别癌。本病例展示了一例发生于下颌下腺的具有肌上皮特征的低级别透明细胞癌，其不同于透明变透明细胞癌和上皮-肌上皮癌。一名32岁男性，有7个月左侧下颌下肿胀病史。行左侧下颌下腺切除及左侧肩胛舌骨肌上颈部清扫术。显微镜下，肿瘤边界清晰，主要由透明卵圆形细胞条索和巢团构成，位于致密透明变的间质中。这些细胞弥漫性表达细胞角蛋白AE1/AE3，局灶性表达波形蛋白和平滑肌肌动蛋白（SMA）。基于这些发现，该肿瘤被诊断为“具有肌上皮特征的低级别透明细胞癌”。术后过程顺利，患者术后21个月无疾病复发。
