Scheyer E Todd, Schupbach Peter, McGuire Michael K
Service and Research Laboratory for Biomaterials, Histology and Imaging, Schupbach Ltd., Horgen, Switzerland.
Int J Periodontics Restorative Dent. 2012 Oct;32(5):543-52.
In an attempt to reduce postextraction alveolar bone resorption, ridge preservation grafting procedures with or without resorbable membranes have become standard-of-care treatments following tooth removal. This prospective case series examined histologic and clinical outcomes following socket grafting with a syringeable paste allograft and a resorbable extracellular matrix membrane at three different time periods following postextraction grafting: 6, 12, and 24 weeks. At each time period, bone core specimens were retrieved for microscopic examination, and implants were placed. Following prosthetic restoration, implants were monitored under long-term occlusal function. At all three time periods, histologic results revealed active bone regeneration. At 6 weeks, localized areas of woven bone were evident, although nonmineralized osteoid was the dominant feature. At 12 and 24 weeks, regenerated woven bone dominated the histologic landscape, with increasing amounts evident in the latter specimens. Regardless of when implants were placed following grafting, implant survival under function occurred.
为了减少拔牙后牙槽骨吸收，使用或不使用可吸收膜的牙槽嵴保存植骨手术已成为拔牙后的标准治疗方法。本前瞻性病例系列研究了在拔牙后移植的三个不同时间段（6周、12周和24周），使用可注射膏状同种异体移植物和可吸收细胞外基质膜进行牙槽窝植骨后的组织学和临床结果。在每个时间段，获取骨芯标本进行显微镜检查，并植入种植体。在进行修复修复后，对种植体进行长期咬合功能监测。在所有三个时间段，组织学结果均显示有活跃的骨再生。在6周时，可见局部编织骨区域，尽管未矿化的类骨质是主要特征。在12周和24周时，再生编织骨在组织学视野中占主导地位，后一组标本中可见量增加。无论移植后何时植入种植体，种植体在功能状态下均存活。
