Arora Poonam, Ansari Shahid, Nazish Iram
Jamia Hamdard.
J Complement Integr Med. 2011 Jan;8. doi: 10.2202/1553-3840.1510.
Grapes seeds are rich source of polyphenolic compounds with potent antioxidant and have been reported beneficial for several health ailments. In the present study, the anti-obesity effect of grape seed extract in an animal model of high fat diet-induced obesity was investigated. Analysis of physiological parameters of high fat diet fed rats when treated with ethanol and water grape seeds extracts revealed significant (P<0.01) decrease in weight gain and food intake when compared with high fat diet rats. The results showed that the organ weight of the liver and adipose tissue weights of mesenteric, perirenal and uterine tissues in the HFD + GSAE and HFD + GSWE groups were significantly decreased as compared with the HFD group. Serum TG, total cholesterol, HDL-cholesterol, glucose levels in the HFD + GSAE and HFD + GSWE groups were significantly decreased as compared with the HFD group. Histological study showed that the lipid droplets of heart and liver of rats with HFD + GSAE and HFD + GSWE diets were significantly smaller than those with HFD diets. These results demonstrate that intake of GSE can be beneficial for the suppression of HFD-induced obesity.
葡萄籽是富含具有强大抗氧化作用的多酚类化合物的来源，并且已有报道称其对多种健康疾病有益。在本研究中，研究了葡萄籽提取物在高脂饮食诱导肥胖的动物模型中的抗肥胖作用。用乙醇和水提取的葡萄籽提取物处理高脂饮食喂养的大鼠后，对其生理参数进行分析，结果显示与高脂饮食大鼠相比，体重增加和食物摄入量显著（P<0.01）降低。结果表明，与高脂饮食组相比，高脂饮食+葡萄籽油提取物（HFD + GSAE）组和高脂饮食+葡萄籽油水溶液提取物（HFD + GSWE）组的肝脏器官重量以及肠系膜、肾周和子宫组织的脂肪组织重量均显著降低。与高脂饮食组相比，高脂饮食+ GSAE组和高脂饮食+ GSWE组的血清甘油三酯、总胆固醇、高密度脂蛋白胆固醇、葡萄糖水平均显著降低。组织学研究表明，高脂饮食+ GSAE和高脂饮食+ GSWE饮食的大鼠心脏和肝脏的脂滴明显小于高脂饮食的大鼠。这些结果表明，摄入葡萄籽油提取物可能有助于抑制高脂饮食诱导的肥胖。
