• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

葡萄籽和葡萄皮提取物的健康影响及其对生化标志物的影响。

Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers.

机构信息

Department of Viticulture and Enology, Faculty of Horticulture, Mendel University in Brno, Valtická 337, 691-44 Lednice, Czech Republic.

Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal and Pathological Physiology, 841-04 Bratislava, Slovakia.

出版信息

Molecules. 2020 Nov 14;25(22):5311. doi: 10.3390/molecules25225311.

DOI:10.3390/molecules25225311
PMID:33202575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7696942/
Abstract

This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that investigate the effects of GSSE on diabetes mellitus, cardiovascular disease and cancer, its neuroprotective effect, and its effects on the gastrointestinal tract and other health complications related to these diseases. The results of the studies confirm that the anti-inflammatory, antiapoptotic, and pro-proliferative effects of " L." seed extract reduce the level of oxidative stress and improve the overall lipid metabolism.

摘要

本综述重点研究了葡萄籽和果皮提取物（GSSE）对人类健康的影响。GSSE 含有高浓度的重要多酚类物质，具有很高的生物活性。本综述总结了研究 GSSE 对糖尿病、心血管疾病和癌症的影响，其神经保护作用，以及对胃肠道和其他与这些疾病相关的健康并发症的影响。研究结果证实，“L”种子提取物的抗炎、抗细胞凋亡和促增殖作用降低了氧化应激水平，改善了整体脂质代谢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/d1f7a24514e5/molecules-25-05311-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/25867e2f3893/molecules-25-05311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/d263ad85536b/molecules-25-05311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/045abf9d1c9e/molecules-25-05311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/1d13d5094933/molecules-25-05311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/b9668fd4b2b0/molecules-25-05311-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/d1f7a24514e5/molecules-25-05311-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/25867e2f3893/molecules-25-05311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/d263ad85536b/molecules-25-05311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/045abf9d1c9e/molecules-25-05311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/1d13d5094933/molecules-25-05311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/b9668fd4b2b0/molecules-25-05311-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/7696942/d1f7a24514e5/molecules-25-05311-g006.jpg

相似文献

1
Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers.葡萄籽和葡萄皮提取物的健康影响及其对生化标志物的影响。
Molecules. 2020 Nov 14;25(22):5311. doi: 10.3390/molecules25225311.
2
Grape seed and skin extract as an adjunct to xenical therapy reduces obesity, brain lipotoxicity and oxidative stress in high fat diet fed rats.葡萄籽和葡萄皮提取物作为 Xenical 治疗的辅助手段可降低高脂饮食喂养大鼠的肥胖、脑脂毒性和氧化应激。
Obes Res Clin Pract. 2018 Jan-Feb;12(Suppl 2):115-126. doi: 10.1016/j.orcp.2016.04.006. Epub 2016 May 6.
3
Neuroprotective Activity of Grape Seed and Skin Extract Against Lithium Exposure Using Proteomic Research.利用蛋白质组学研究探讨葡萄籽和葡萄皮提取物对锂暴露的神经保护活性。
Mol Neurobiol. 2017 May;54(4):2720-2730. doi: 10.1007/s12035-016-9853-y. Epub 2016 Mar 21.
4
Supplementation of grape seed and skin extract to orlistat therapy prevents high-fat diet-induced murine spleen lipotoxicity.葡萄籽和皮提取物补充到奥利司他治疗中可预防高脂饮食诱导的小鼠脾脏脂肪毒性。
Appl Physiol Nutr Metab. 2018 Aug;43(8):782-794. doi: 10.1139/apnm-2017-0743. Epub 2018 Mar 7.
5
Efficacy of grape seed and skin extract against doxorubicin-induced oxidative stress in rat liver.葡萄籽和葡萄皮提取物对阿霉素诱导的大鼠肝脏氧化应激的功效。
Pak J Pharm Sci. 2015 Nov;28(6):1971-8.
6
Proanthocyanidins from Vitis vinifera inhibit oxidative stress-induced vascular impairment in pulmonary arteries from diabetic rats.从酿酒葡萄的原花青素抑制氧化应激诱导的糖尿病大鼠肺动脉血管损伤。
Phytomedicine. 2017 Feb 15;25:39-44. doi: 10.1016/j.phymed.2016.12.015. Epub 2016 Dec 23.
7
Grape seed and skin extract reduces pancreas lipotoxicity, oxidative stress and inflammation in high fat diet fed rats.葡萄籽和葡萄皮提取物可降低高脂肪饮食喂养大鼠的胰腺脂肪毒性、氧化应激和炎症。
Biomed Pharmacother. 2016 Dec;84:2020-2028. doi: 10.1016/j.biopha.2016.11.017. Epub 2016 Nov 12.
8
Protective effects of grape seed and skin extract against high-fat-diet-induced lipotoxicity in rat lung.葡萄籽和皮提取物对高脂饮食诱导的大鼠肺脂毒性的保护作用。
Lipids Health Dis. 2017 Sep 13;16(1):174. doi: 10.1186/s12944-017-0561-z.
9
Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet.葡萄(Vitis vinifera)提取物对高脂饮食诱导的糖尿病前期小鼠的神经保护作用。
Korean J Intern Med. 2013 Sep;28(5):579-86. doi: 10.3904/kjim.2013.28.5.579. Epub 2013 Aug 14.
10
Grape seed and skin extract mitigates garlic-induced oxidative stress in rat liver.葡萄籽和葡萄皮提取物可减轻大蒜引起的大鼠肝氧化应激。
Can J Physiol Pharmacol. 2012 May;90(5):547-56. doi: 10.1139/y2012-025. Epub 2012 Apr 19.

引用本文的文献

1
Variability in seed oil content, fatty acids profile, phytochemical properties, mineral and proximate composition of Iranian cultivars of vitis vinifera L.伊朗酿酒葡萄品种种子油含量、脂肪酸谱、植物化学特性、矿物质及近似成分的变异性
Sci Rep. 2025 Jul 2;15(1):23210. doi: 10.1038/s41598-025-06283-4.
2
Development and Optimization of Grape Skin Extract-Loaded Gelatin-Alginate Hydrogels: Assessment of Antioxidant and Antimicrobial Properties.负载葡萄皮提取物的明胶-海藻酸盐水凝胶的研制与优化：抗氧化和抗菌性能评估
Pharmaceutics. 2025 Jun 17;17(6):790. doi: 10.3390/pharmaceutics17060790.
3
Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training.

本文引用的文献

1
The Study of Antioxidant Components in Grape Seeds.葡萄籽中抗氧化成分的研究。
Molecules. 2020 Aug 15;25(16):3736. doi: 10.3390/molecules25163736.
2
Investigating the relationship between grape cell wall polysaccharide composition and the extractability of phenolic compounds into Shiraz wines. Part I: Vintage and ripeness effects.研究葡萄细胞壁多糖组成与酚类化合物在设拉子葡萄酒中浸提率之间的关系。第一部分：年份和成熟度的影响。
Food Chem. 2019 Apr 25;278:36-46. doi: 10.1016/j.foodchem.2018.10.134. Epub 2018 Oct 30.
3
Use of monomeric and oligomeric flavanols in the dietary management of patients with type 2 diabetes mellitus and microalbuminuria (FLAVA trial): study protocol for a randomized controlled trial.
原花青素和不同强度运动训练对心肌缺血中与Myh7和Myh6相关的微小RNA谱的调控作用
Avicenna J Phytomed. 2025 Jan-Feb;15(1):874-889. doi: 10.22038/AJP.2024.24739.
4
Enhanced formulation and comprehensive analysis of novel natural ointments with grape seed and pomegranate peel infused in olive oil.新型天然软膏的强化配方及综合分析：橄榄油中注入葡萄籽和石榴皮提取物
Turk J Biol. 2024 Dec 16;49(1):28-39. doi: 10.55730/1300-0152.2721. eCollection 2025.
5
Biologically Synthesized Gold Nanoparticles with Enhanced Antioxidant and Catalytic Properties.具有增强抗氧化和催化性能的生物合成金纳米颗粒。
Pharmaceuticals (Basel). 2024 Aug 23;17(9):1105. doi: 10.3390/ph17091105.
6
Antimicrobial Polymer Films with Grape Seed and Skin Extracts for Food Packaging.含葡萄籽和葡萄皮提取物的用于食品包装的抗菌聚合物薄膜
Microorganisms. 2024 Jul 6;12(7):1378. doi: 10.3390/microorganisms12071378.
7
Comparative Analysis of Grape Seed Oil, Linseed Oil, and a Blend: In Vivo Effects of Supplementation.葡萄籽油、亚麻籽油及其混合物的比较分析：补充剂的体内效应
Foods. 2024 Jul 20;13(14):2283. doi: 10.3390/foods13142283.
8
Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis.高血压患者使用草药的安全性分类：一项系统评价与荟萃分析。
Front Pharmacol. 2024 May 31;15:1321523. doi: 10.3389/fphar.2024.1321523. eCollection 2024.
9
Dietary supplementation with grape seed extract from Vitus vinifera prevents suppression of GABAergic protein expression in female Sprague Dawley trigeminal ganglion in a model of chronic temporomandibular joint disorder.在慢性颞下颌关节紊乱模型中，用葡萄（Vitus vinifera）葡萄籽提取物进行膳食补充可防止雌性斯普拉格-道利大鼠三叉神经节中γ-氨基丁酸能蛋白表达受到抑制。
Arch Oral Biol. 2024 Sep;165:106014. doi: 10.1016/j.archoralbio.2024.106014. Epub 2024 May 29.
10
Fabrication, characterization and application of Pickering emulsion gels stabilized by defatted grape seed powder.由脱脂葡萄籽粉稳定的皮克林乳液凝胶的制备、表征及应用
Food Chem X. 2024 May 16;22:101476. doi: 10.1016/j.fochx.2024.101476. eCollection 2024 Jun 30.
单体和低聚黄烷醇在2型糖尿病合并微量白蛋白尿患者饮食管理中的应用（FLAVA试验）：一项随机对照试验的研究方案
Trials. 2018 Jul 16;19(1):379. doi: 10.1186/s13063-018-2762-9.
4
Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology.葡萄籽原花青素提取物通过调节炎症、肿瘤抑制蛋白p53、神经递质、氧化应激和组织学对卡铂和沙利度胺的神经保护和肾保护作用
Toxicol Rep. 2018 Apr 30;5:568-578. doi: 10.1016/j.toxrep.2018.04.006. eCollection 2018.
5
Protective effect of grape seed and skin extract against high-fat diet-induced dyshomeostasis of energetic metabolism in rat lung.葡萄籽和葡萄皮提取物对高脂肪饮食诱导的大鼠肺能量代谢失调的保护作用。
Lipids Health Dis. 2018 May 10;17(1):109. doi: 10.1186/s12944-018-0754-0.
6
Intestinal Absorption and Antioxidant Activity of Grape Pomace Polyphenols.葡萄渣多酚的肠道吸收和抗氧化活性。
Nutrients. 2018 May 9;10(5):588. doi: 10.3390/nu10050588.
7
Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity.葡萄籽原花青素提取物抗肺癌：微小RNA-106b的作用、生物利用度及生物活性
Oncotarget. 2018 Feb 16;9(21):15579-15590. doi: 10.18632/oncotarget.24528. eCollection 2018 Mar 20.
8
Grape seed extract effects on serum amylase levels and immunohistochemical alterations in Streptozotocin-induced diabetic rats.葡萄籽提取物对链脲佐菌素诱导的糖尿病大鼠血清淀粉酶水平及免疫组化改变的影响。
Cell Mol Biol (Noisy-le-grand). 2018 Mar 31;64(4):92-97.
9
INFLUENCE OF POMEGRANATE SEED OIL AND GRAPE SEED OIL ON CHOLESTEROL CONTENT AND FATTY ACIDS PROFILE IN LIVERS OF CHICKENS.石榴籽油和葡萄籽油对鸡肝脏胆固醇含量及脂肪酸谱的影响
Acta Pol Pharm. 2017 Mar;74(2):624-632.
10
Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells.秋皇家葡萄和里比埃葡萄汁提取物降低结肠癌细胞的活力和转移潜力。
Evid Based Complement Alternat Med. 2018 Jan 14;2018:2517080. doi: 10.1155/2018/2517080. eCollection 2018.