Ting Yuwen, Chang Wei-Tang, Shiau Duen-Kai, Chou Pei-Hsuan, Wu Mei-Fang, Hsu Chin-Lin
Graduate Institute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.
Department of Nutrition, Chung Shan Medical University , Taichung, Taiwan.
J Agric Food Chem. 2018 Jan 10;66(1):70-80. doi: 10.1021/acs.jafc.7b03551. Epub 2017 Dec 26.
The antiobesity effects of quercetin-rich supplement (QRS), which contain quercetin, lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated the final body weights [490 ± 11 (HFD) → 441 ± 11 (HFD+QRS) g], total body fat [112.9 ± 4.5 (HFD) → 86.6 ± 5.7 (HFD+QRS) g], liver weights [14.8 ± 0.4 (HFD) → 12.6 ± 0.4 (HFD+QRS) g/rat], and the serum TG [102.5 ± 7.3 (HFD) → 90.7 ± 6.5 (HFD+QRS) mg/dL] to a level that resembled the regular diet-consumed rats (p < 0.05). The excretion of lipid in the faeces augmented in QRS groups as compared with the nonsupplemented HFD group [faecal total lipid: 62.43 ± 2.80 (HFD) → 73.15 ± 0.88 (HFD+QRS) mg/g dried faeces, p < 0.05]. In the histological analysis, quercetin-rich formulation supplemented groups presented a much less lipid accumulation and smaller size of adipocytes. Moreover, a decreased serum thiobarbituric acid reactive substances [1.55 ± 0.17 (HFD) → 0.78 ± 0.04 (HFD+QRS) nmol MDA eq/mL serum] increased levels of serum Trolox equivalent antioxidant capacity [3.89 ± 0.08 (HFD) → 6.46 ± 0.20 (HFD+QRS) μmol/mL serum], and more active hepatic antioxidant enzymes were observed in the supplemented groups (p < 0.05). The result of this work is a good demonstration of how a combination of bioactive compounds could work synergistically and become very effective in disease prevention.
研究了富含槲皮素的补充剂（QRS）对高脂饮食（HFD）诱导的肥胖大鼠的抗肥胖作用，QRS含有槲皮素、番茄红素、牛磺酸和荔枝花提取物。食用含QRS（185毫克/千克大鼠）的高脂饮食的大鼠，其最终体重[490±11（高脂饮食组）→441±11（高脂饮食+QRS组）克]、总体脂肪[112.9±4.5（高脂饮食组）→86.6±5.7（高脂饮食+QRS组）克]、肝脏重量[14.8±0.4（高脂饮食组）→12.6±0.4（高脂饮食+QRS组）克/大鼠]和血清甘油三酯[102.5±7.3（高脂饮食组）→90.7±6.5（高脂饮食+QRS组）毫克/分升]均显著调节至与正常饮食大鼠相似的水平（p<0.05）。与未补充QRS的高脂饮食组相比，QRS组大鼠粪便中的脂质排泄增加[粪便总脂质：62.43±2.80（高脂饮食组）→73.15±0.88（高脂饮食+QRS组）毫克/克干粪便，p<0.05]。组织学分析显示，补充富含槲皮素制剂的组脂质积累明显减少，脂肪细胞尺寸更小。此外，补充组血清硫代巴比妥酸反应性物质减少[1.55±0.17（高脂饮食组）→0.78±0.04（高脂饮食+QRS组）纳摩尔丙二醛当量/毫升血清]，血清Trolox等效抗氧化能力水平升高[3.89±0.08（高脂饮食组）→6.46±0.20（高脂饮食+QRS组）微摩尔/毫升血清]，且肝脏抗氧化酶活性更高（p<0.05）。这项研究结果很好地证明了生物活性化合物的组合如何协同发挥作用，并在疾病预防中变得非常有效。
