Wright J D, Font R L
Cancer. 1979 Nov;44(5):1757-68. doi: 10.1002/1097-0142(197911)44:5<1757::aid-cncr2820440533>3.0.co;2-8.
This is a clinicopathologic study of 21 cases of mucinous sweat gland adenocarcinoma involving the eyelid. The tumor occurred in middle-aged adults (median age 60 years) and has a predilection for males. In this series eight patients (40%) had one or more local recurrences, one of whom died with extensive local invasion of the face after multiple recurrences in a 15-year interval. Only one patient had metastasis to the submandibular lymph nodes, which was treated by radical neck dissection. Involvement of the head, especially the face and scalp, was observed in 78% of the cases from the literature. Combining our cases with those previously reported, we found that the eyelid was involved in almost half of the cases (21 out of 45 lesions). We believe that the identification by light microscopy of a mixed population of light and dark secretory cells within the tumor lobules, the histochemical findings (presence of sialomucin and absence of iron as well as periodic acid-Schiff positive, diastase-resistant granules), and the results of ultrastructural studies support the histogenetic postulate that this mucinous adenocarcinoma is probably derived from the secretory cells of the eccrine coil. Our interpretation concurs with Headington's view of origin from the eccrine glands.
这是一项关于21例累及眼睑的黏液性汗腺腺癌的临床病理研究。肿瘤发生于中年成年人（中位年龄60岁），且男性更易受累。在这组病例中，8例患者（40%）出现一次或多次局部复发，其中1例在15年期间多次复发后因面部广泛局部侵犯而死亡。仅有1例患者发生下颌下淋巴结转移，接受了根治性颈部清扫术。据文献报道，78%的病例累及头部，尤其是面部和头皮。将我们的病例与先前报道的病例相结合，我们发现几乎一半的病例（45个病变中的21个）累及眼睑。我们认为，通过光学显微镜在肿瘤小叶内识别出浅色和深色分泌细胞的混合群体、组织化学结果（存在涎黏蛋白且无铁以及过碘酸-希夫阳性、抗淀粉酶颗粒）以及超微结构研究结果支持了该黏液腺癌可能起源于小汗腺螺旋分泌细胞的组织发生学假说。我们的解释与海丁顿关于起源于小汗腺的观点一致。
