Takeya M, Matsuzaki H, Hata H, Takatsuki K, Takahashi K
Second Department of Pathology, Kumamoto University Medical School, Japan.
Virchows Arch A Pathol Anat Histopathol. 1989;415(3):219-24. doi: 10.1007/BF00724908.
The first autopsy case of amylase-producing IgA-lambda-type multiple myeloma is described. Immunohistochemically, amylase and alpha and lambda chains of immunoglobulin were demonstrated in the cytoplasm of the myeloma cells. Secretion of amylase by cultured myeloma cells obtained from the patient's pleural effusion was clearly demonstrated by the starch film method. Immunoelectron microscopically, positive reaction products for amylase and the alpha chain of immunoglobulin were observed in the well developed endoplasmic reticulum. Since no secretory granules were observed, we postulated that the secretory process of amylase was not via the zymogen granules but via a mechanism similar to that for immunoglobulin.
本文描述了首例产生淀粉酶的IgA-λ型多发性骨髓瘤尸检病例。免疫组织化学检查显示，骨髓瘤细胞的细胞质中存在淀粉酶以及免疫球蛋白的α链和λ链。通过淀粉膜法清楚地证明了从患者胸腔积液中获取的培养骨髓瘤细胞能够分泌淀粉酶。免疫电子显微镜检查发现，在发育良好的内质网中观察到淀粉酶和免疫球蛋白α链的阳性反应产物。由于未观察到分泌颗粒，我们推测淀粉酶的分泌过程不是通过酶原颗粒，而是通过一种类似于免疫球蛋白的机制。
