Calmettes C
INSERM U 113, CHU Saint-Antoine, Paris, France.
Bull Cancer. 1990;77(11):1063-72.
Medullary thyroid cancer (MTC) is either of the sporadic or familial type, whether it be isolated or constitute part of a type II multiple endocrine neoplasia. Progress in the knowledge of the disease has recently been obtained in the following ways: the IRMA assay of mature calcitonin, the disease marker, has permitted earlier diagnosis of familial cases and recurrence; the locus assignment of the gene on chromosome 10 now enables a valid discrimination in certain families of gene carriers; collaborative clinical, biological, pathological, therapeutic and epidemiological research on a nation-wide scale has had a beneficial effect on patients, with improvement in diagnosis of the familial forms, in disease prognosis, in cancer detection at an infraclinical stage, and in the regrouping and distribution of families in France.
甲状腺髓样癌（MTC）可为散发性或家族性，可为孤立性或构成II型多发性内分泌肿瘤的一部分。最近在该疾病的认知方面取得了以下进展：作为疾病标志物的成熟降钙素的免疫放射分析（IRMA）检测，已能对家族性病例进行更早诊断及复发监测；10号染色体上该基因的定位，现在能够在某些家族中有效鉴别基因携带者；全国范围内开展的临床、生物学、病理学、治疗学及流行病学合作研究，已对患者产生了有益影响，包括改善家族性形式的诊断、疾病预后、亚临床阶段癌症的检测，以及法国各家族的重新分组和分布情况。
