Calmettes C, Chaventre A, Feingold N, Franc B, Guliana J M
Henry Ford Hosp Med J. 1989;37(3-4):120-1.
Screening for medullary thyroid cancer (MTC) in France is based on a protocol that has been widely distributed nationally. A network of coordinators utilizing a common questionnaire provides for an effective national screening program. Calcitonin stimulation procedures are systematically used for all first-degree relatives of MTC patients. Pathological studies utilize special immunopathologic techniques. Genealogic information is obtained on all index cases, and blood specimens are collected for establishing permanent cell lines. The data collected are used not only to establish the diagnosis of the hereditary or sporadic form of the disease but also to expand the screening as appropriate. This common protocol has benefited patients and their families by improving early detection of cases, increasing the number of families available for follow-up, and improving the prognosis of this cancer. Studies on these families have contributed significantly to the localization of the multiple endocrine neoplasia type 2 gene.
法国的甲状腺髓样癌（MTC）筛查基于一项已在全国广泛传播的方案。由协调员组成的网络使用通用问卷来开展有效的全国筛查计划。对所有MTC患者的一级亲属系统地采用降钙素刺激程序。病理研究采用特殊的免疫病理技术。获取所有索引病例的系谱信息，并采集血样以建立永久细胞系。收集到的数据不仅用于确定疾病的遗传型或散发型诊断，还用于酌情扩大筛查范围。这一通用方案通过改善病例的早期发现、增加可供随访的家庭数量以及改善这种癌症的预后，使患者及其家庭受益。对这些家庭的研究为2型多发性内分泌腺瘤病基因的定位做出了重大贡献。
