UBA, CEFYBO-CONICET, 1(a)Cátedra de Farmacología, Facultad de Medicina, Paraguay 2155 piso 15, 1121 Buenos Aires, Argentina.
Brain Res. 2012 Aug 30;1471:1-12. doi: 10.1016/j.brainres.2012.06.022. Epub 2012 Jul 1.
Noise exposure is known to affect auditory structures in living organisms. However, it should not be ignored that many of the effects of noise are extra-auditory. Previous findings of our laboratory demonstrated that noise was able to induce behavioral alterations that are mainly related to the cerebellum (CE) and the hippocampus (HC). Therefore, the aim of this work was to reveal new data about the vulnerability of developing rat HC to moderate noise levels through the assessment of potential histological changes and hippocampal-related behavioral alterations. Male Wistar rats were exposed to noise (95-97 dB SPL, 2h daily) either for 1 day (acute noise exposure, ANE) or between postnatal days 15 and 30 (sub-acute noise exposure, SANE). Hippocampal histological evaluation as well as short (ST) and long term (LT) habituation and recognition memory assessments were performed. Results showed a mild disruption in the different hippocampal regions after ANE and SANE schemes, along with significant behavioral abnormalities. These data suggest that exposure of developing rats to noise levels of moderate intensity is able to trigger changes in the HC, an extra-auditory structure of the Central Nervous System (CNS), that could underlie the observed behavioral effects.
噪声暴露已知会影响生物体的听觉结构。然而，不应忽视的是，噪声的许多影响都是听觉外的。我们实验室的先前研究结果表明，噪声能够诱导主要与小脑（CE）和海马体（HC）相关的行为改变。因此，本工作的目的是通过评估潜在的组织学变化和与海马体相关的行为改变，揭示发育中的大鼠 HC 对中等噪声水平易感性的新数据。雄性 Wistar 大鼠接受噪声（95-97 dB SPL，每天 2 小时）暴露，分别为 1 天（急性噪声暴露，ANE）或在出生后第 15 天至第 30 天（亚急性噪声暴露，SANE）。进行了海马组织学评估以及短期（ST）和长期（LT）习惯化和识别记忆评估。结果表明，ANE 和 SANE 方案后不同海马区出现轻度紊乱，并伴有明显的行为异常。这些数据表明，发育中的大鼠暴露于中等强度的噪声水平能够引发中枢神经系统（CNS）的听觉外结构 HC 的变化，这可能是观察到的行为效应的基础。
