Pós-Graduação em Medicina e Saúde Humana, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil.
Rev Soc Bras Med Trop. 2012 Jun;45(3):305-8. doi: 10.1590/s0037-86822012000300005.
HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection.
A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR).
The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected.
The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.
HTLV-1 感染会增加感染其他感染的易感性。很少有研究涉及 HPV 和 HTLV-1 的合并感染以及这种相互作用中的免疫反应。本研究旨在确定 HTLV-1 感染妇女中宫颈 HPV 感染的流行率，并确定这种合并感染涉及的危险因素。
这是一项在巴西萨尔瓦多进行的横断面研究，于 2005 年 9 月至 2008 年 12 月进行，涉及 HTLV 参考中心的 50 名 HTLV-1 感染妇女和妇科诊所的 40 名未感染患者，均来自巴伊亚医学院。使用杂交捕获法评估 HPV 感染。使用实时聚合酶链反应（PCR）定量 HTLV-1 前病毒载量。
HTLV-1 感染妇女的平均年龄（38 ± 10 岁）与对照组相似（36 ± 13 岁）。HTLV-1 感染组 HPV 感染的患病率为 44%，未感染组为 22.5%（p = 0.03）。与对照组相比，HTLV-1 感染妇女的性活跃年龄更早（17 ± 3 岁对 19 ± 3 岁；p = 0.03），且性伴侣数量更多（4 ± 3 对 2 ± 1；p < 0.01）。在 HTLV-1 感染患者组中，HPV 感染的 HTLV-1 前病毒载量在感染妇女和未感染妇女之间没有差异。
HTLV-1 感染妇女 HPV 感染的流行率较高。应进一步开展研究，以评估这种合并感染的进展。
