Lenz F A, Kwan H C, Dostrovsky J O, Tasker R R, Murphy J T, Lenz Y E
Department of Neurosurgery, Johns Hopkins University, Baltimore, MD.
Brain. 1990 Dec;113 ( Pt 6):1795-821. doi: 10.1093/brain/113.6.1795.
During neurosurgical operations for the relief of movement disorders, single thalamic neurons (n = 107) were identified with activity which was related to verbally cued active movements (movement-related cells). The activity of each neuron was examined during different contralateral movements in order to determine the movement which was associated with the most consistent and pronounced change in firing rate (the optimal response). The optimal response was determined by analysis of histograms of neuronal activity which were constructed by using the onset of EMG activity to synchronize successive repetitions of the active movement. Movement-related cells exhibited optimal responses associated with such movements as making a fist, extension or flexion of the wrist, flexing or extending the elbow, pointing with the entire upper extremity, extending the tongue and lifting the leg. Most movement-related cells recorded in a single parasagittal plane in an individual patient had optimal responses related to movements involving the same part of the body. Movement-related cells were classified into those that were activated in response to somatosensory stimulation (combined cells, n = 20) and those which were not (voluntary cells, n = 87). Combined cells were activated in advance of EMG activity during active movement and so could be distinguished from cells responding only to sensory stimulation (sensory cells). Movement-related cells (combined and voluntary cell types) were located anterior to sensory cells and tended to show a mediolateral somatotopic organization parallel to that of sensory cells with cutaneous receptive fields. Combined cells responded to somatosensory stimulation of the same part of the body as that involved in the active movement related to the optimal response of the cell. Combined cells responding to passive movements of a joint always had their optimal response during active movement about the same joint. The activity of combined cells during parkinsonian tremor may clarify the role of sensory feedback in tremor.
在为缓解运动障碍而进行的神经外科手术过程中，识别出了107个单丘脑神经元，其活动与言语提示的主动运动相关（运动相关细胞）。在不同的对侧运动过程中检查每个神经元的活动，以确定与放电率最一致且最明显变化相关的运动（最佳反应）。通过分析神经元活动直方图来确定最佳反应，这些直方图是利用肌电图活动的起始来同步主动运动的连续重复构建而成的。运动相关细胞表现出与诸如握拳、手腕伸展或弯曲、肘部弯曲或伸展、整个上肢指物、伸舌和抬腿等运动相关的最佳反应。在个体患者的单个矢状旁平面中记录的大多数运动相关细胞具有与涉及身体同一部位的运动相关的最佳反应。运动相关细胞被分为对体感刺激有反应而激活的细胞（联合细胞，n = 20）和无反应的细胞（自主细胞，n = 87）。联合细胞在主动运动期间在肌电图活动之前被激活，因此可以与仅对感觉刺激有反应的细胞（感觉细胞）区分开来。运动相关细胞（联合和自主细胞类型）位于感觉细胞前方，并且倾向于显示与具有皮肤感受野的感觉细胞平行的中外侧躯体定位组织。联合细胞对与该细胞最佳反应相关的主动运动所涉及身体同一部位的体感刺激有反应。对关节被动运动有反应的联合细胞在围绕同一关节的主动运动期间总是具有其最佳反应。联合细胞在帕金森震颤期间的活动可能阐明感觉反馈在震颤中的作用。
