Sadovnick A D, Hashimoto L L, Hashimoto S A
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Can J Neurol Sci. 1990 Nov;17(4):387-90. doi: 10.1017/s0317167100030936.
Once diagnosed to have MS, relatives of persons who have been previously diagnosed frequently ask whether their disease course will follow that of their relative(s) with MS. The present study compared the following clinical manifestations of MS among 43 index cases and 47 of their relatives, all of whom were diagnosed to have MS and regularly attended the MS Clinic in Vancouver, British Columbia: (i) age of onset of MS, (ii) clinical course, (iii) lesion site(s) and (iv) initial symptom(s) of MS. The results from the present study are preliminary because of the small size of the study group. However, these data suggest that apart from possibly age of onset between sibling pairs, the clinical manifestations of MS are not correlated among relatives who are assessed according to the same methodology. This is significant for counselling newly diagnosed relatives of longstanding MS patients.
一旦被诊断患有多发性硬化症（MS），先前已被诊断出患有该病的患者的亲属常常会问，他们的病程是否会与患MS的亲属相同。本研究比较了43例索引病例及其47名亲属的MS以下临床表现，所有这些人都被诊断患有MS并定期前往不列颠哥伦比亚省温哥华市的MS诊所就诊：（i）MS的发病年龄，（ii）临床病程，（iii）病变部位，以及（iv）MS的初始症状。由于研究组规模较小，本研究结果是初步的。然而，这些数据表明，除了同胞对之间可能存在的发病年龄差异外，按照相同方法评估的亲属之间MS的临床表现并无相关性。这对于为长期患MS患者的新诊断亲属提供咨询具有重要意义。
