Sadovnick A D, Baird P A, Ward R H
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Am J Med Genet. 1988 Mar;29(3):533-41. doi: 10.1002/ajmg.1320290310.
Two important characteristics of multiple sclerosis (MS) are familial clustering and a variable age of onset. There is increasing evidence for a genetically influenced susceptibility in MS. Because of this, patients and their relatives are increasingly asking about the risk for relatives of developing MS. In the MS Clinic in Vancouver, genetic histories are taken routinely for all patients and are updated annually. Patients do not attend the clinic specifically to participate in genetic studies, which could result in over-representation of familial cases. Data were available for 815 MS index cases and 11,345 of their relatives. Age-specific MS risks were calculated for first-, second-, and third-degree relatives of probands and are presented in an easy-reference format. In general, first-degree relatives of probands have a risk that is 30-50 times greater than the 0.1% risk for the general population.
多发性硬化症（MS）的两个重要特征是家族聚集性和发病年龄的差异。越来越多的证据表明MS存在受遗传影响的易感性。因此，患者及其亲属越来越多地询问亲属患MS的风险。在温哥华的MS诊所，会为所有患者常规采集遗传病史，并每年更新。患者并非专门为参与基因研究而就诊，这可能导致家族性病例的比例过高。我们获取了815例MS索引病例及其11345名亲属的数据。计算了先证者一级、二级和三级亲属的年龄特异性MS风险，并以易于参考的格式呈现。一般来说，先证者的一级亲属患MS的风险比普通人群0.1%的风险高30至50倍。
