Weinshenker B G, Bulman D, Carriere W, Baskerville J, Ebers G C
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Neurology. 1990 Sep;40(9):1354-8. doi: 10.1212/wnl.40.9.1354.
We compared demographic and clinical features, including outcome defined by a failure time analysis of disability, in 143 patients with a family history of multiple sclerosis (familial MS) compared with 956 patients without such a history (sporadic MS). Patients with familial MS did not differ from those with sporadic MS even when patients with 1st-degree relatives or multiple relatives with MS were considered separately. An intraclass correlation analysis of 13 pairs of affected 1st-degree relatives, both members of which were followed in our clinic, failed to reveal heterogeneity among different families. We were unable to find any support for differences between familial and sporadic MS.
我们比较了143例有多发性硬化症家族史（家族性多发性硬化症）患者与956例无此家族史（散发性多发性硬化症）患者的人口统计学和临床特征，包括通过残疾时间分析定义的结局。即使分别考虑有一级亲属或多个亲属患多发性硬化症的患者，家族性多发性硬化症患者与散发性多发性硬化症患者也没有差异。对13对受影响的一级亲属进行的组内相关分析未能揭示不同家族之间的异质性，这13对亲属的双方均在我们诊所接受随访。我们找不到任何证据支持家族性和散发性多发性硬化症之间存在差异。
