Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY, USA.
Wiley Interdiscip Rev Syst Biol Med. 2012 Sep-Oct;4(5):443-56. doi: 10.1002/wsbm.1182. Epub 2012 Jul 3.
Cells in the pluripotent state have the ability to self-renew indefinitely and to differentiate to all the cells of the embryo. These cells provide an in vitro window into development, including human development, as well as holding extraordinary promise for cell-based therapies in regenerative medicine. The recent demonstration that somatic cells can be reprogrammed to the pluripotent state has raised the possibility of patient and disease-specific induced pluripotent cells. In this article, we review the molecular underpinning of pluripotency. We focus on the transcriptional and signaling networks that underlie the state of pluripotency and control differentiation. In general, the action of each of the molecular components and pathways is dose and context dependent highlighting the need for a systems approach to understanding pluripotency.
多能状态的细胞具有无限自我更新和分化为胚胎所有细胞的能力。这些细胞为体外发育提供了一个窗口，包括人类发育，并且在再生医学的基于细胞的治疗中具有非凡的前景。最近的研究表明，体细胞可以被重编程为多能状态，这增加了患者和疾病特异性诱导多能细胞的可能性。在本文中，我们回顾了多能性的分子基础。我们专注于转录和信号转导网络，这些网络是多能状态的基础，并控制分化。一般来说，每个分子成分和途径的作用都是剂量和上下文依赖的，这突出了需要系统方法来理解多能性。
