Zhang Yuqiao, He Hua, Yu Qinwei, Song Xingya, Ma Jun, Wang Jiamei, Wang Yongpan, Jiang Yu, Xu Zejun, Wang Xianwei, Huang Yongzhen
College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi, 712100, People's Republic of China.
College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi, 712100, People's Republic of China.
BMC Genomics. 2025 Jul 26;26(1):693. doi: 10.1186/s12864-025-11878-2.
Bohuai goat is a crossbreeding breed between Huai goat and Boer goat, which has higher meat yield and reproductive efficiency. To explore the genetic basis of these traits, we sequenced the whole genome of 289 samples from 8 Chinese local goat populations and Boer goats. Through variation detection and genetic diversity analysis, we identified 68,166,098 SNPs and assessed genetic diversity parameters such as nucleotide diversity, linkage disequilibrium, and homozygous regions (ROH). The analysis of population structure showed that there was a close genetic relationship between Bohuai goat and Boer goat, which was significantly different from that of Chinese native breeds. Fst, Pi_ratio and XPEHH methods were used to analyze the low reproduction rate population of Bohuai goat.. We found a strong selection in a region of BMPR1B on chr6, which may be associated with the high fertility of Bohuai goats and was also detected in the Vst. In addition, a CNVR fragment (GLIS3 gene) was found to be associated with spermatogenesis in the detection of CNV analysis. Our results provide insights for understanding the genetic diversity and selection of reproductive traits of Bohuai goats. They also offer evidence for the correlation between the BMPR1B gene and reproductive traits and provide information for molecular breeding strategies of other goat breeds.
波淮山羊是淮山羊和波尔山羊的杂交品种，具有较高的产肉量和繁殖效率。为了探究这些性状的遗传基础，我们对来自8个中国本地山羊群体和波尔山羊的289个样本进行了全基因组测序。通过变异检测和遗传多样性分析，我们鉴定出68,166,098个单核苷酸多态性（SNP），并评估了核苷酸多样性、连锁不平衡和纯合区域（ROH）等遗传多样性参数。群体结构分析表明，波淮山羊与波尔山羊之间存在密切的遗传关系，这与中国本土品种有显著差异。使用Fst、Pi_ratio和XPEHH方法对波淮山羊低繁殖率群体进行分析。我们发现在6号染色体上的BMPR1B区域存在强烈选择，这可能与波淮山羊的高繁殖力有关，并且在Vst中也检测到了这一现象。此外，在拷贝数变异（CNV）分析检测中发现一个CNVR片段（GLIS3基因）与精子发生有关。我们的研究结果为理解波淮山羊的遗传多样性和繁殖性状选择提供了见解。它们还为BMPR1B基因与繁殖性状之间的相关性提供了证据，并为其他山羊品种的分子育种策略提供了信息。
