Mansouri Mahboubeh, Pourpak Zahra, Mozafari Habibeh, Abdollah Gorji Fatemeh, Shokouhi Shoormasti Raheleh
Department of Immunology and Allergy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2012 Jun;11(2):157-63.
Allergy to wheat is a common food allergy. In spite of this fact, there is not enough literature regarding the features and outgrowing of this allergy. The objective of this study was to evaluate the manifestations of this allergy and to follow the patients to evaluate whether outgrowing allergy happens again and when it occurs.Eight wheat allergic patients diagnosed between 2000 and 2001 were re-evaluated together with 13 other new cases of wheat allergy referred to the Immunology and Allergy Pediatric Department from June 2004 to March 2006. For all cases, the demographic data along with a complete history regarding allergy to wheat and other types of allergy were collected in questionnaires. The specific IgE measurements (in vivo and in vitro) and oral food challenge (in the absence of a relevant history related to allergy to wheat) were performed. Severe anaphylaxis was seen after wheat ingestion in more than 90% of the patients. Oral tolerance to wheat developed in three patients (37.5%) out of 8 known previous cases who had been followed for eight years, the mean age of oral tolerance to wheat was 68 ± 6.36 (range; 36 months to 108 months).Clinical reactions in our wheat-allergic patients were more severe than those reported before. These patients were at risk for developing chronic allergic symptoms such as asthma. We also found that oral tolerance to wheat was happening in a minority of our patients.
小麦过敏是一种常见的食物过敏。尽管如此，关于这种过敏的特征和自然消退情况的文献并不充足。本研究的目的是评估这种过敏的表现，并对患者进行随访，以评估过敏是否会再次自然消退以及何时发生。对2000年至2001年期间诊断出的8例小麦过敏患者，以及2004年6月至2006年3月转诊至免疫与过敏儿科的其他13例小麦过敏新病例进行了重新评估。对于所有病例，通过问卷调查收集人口统计学数据以及关于小麦过敏和其他类型过敏的完整病史。进行了特异性IgE测量（体内和体外）以及口服食物激发试验（在没有与小麦过敏相关的病史的情况下）。超过90%的患者在摄入小麦后出现严重过敏反应。在8例已知的既往病例中，有3例（37.5%）经过8年随访后对小麦产生了口服耐受性，产生口服耐受性的平均年龄为68±6.36（范围：36个月至108个月）。我们的小麦过敏患者的临床反应比之前报道的更为严重。这些患者有发展为慢性过敏症状如哮喘的风险。我们还发现，我们的患者中只有少数对小麦产生了口服耐受性。
