Movement Disorders Program, Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH 44195, USA.
Cleve Clin J Med. 2012 Jul;79 Suppl 2:S14-8. doi: 10.3949/ccjm.79.s2a.03.
Nonmotor manifestations are integral components of Parkinson disease (PD), and they often have a greater impact on disability and quality of life than the motor features that currently define the illness. Nonmotor features of PD, such as dementia, may be an intrinsic feature of the disorder and persist regardless of the medication state (ie, they continue to manifest in the "on" or "off" state); some nonmotor features, such as psychotic symptoms, may be iatrogenic complications of pharmacologic intervention for the treatment of the motor manifestations of PD. Iatrogenic complications, such as psychosis and impulse control disorders, may respond to modification of the PD treatment regimen at the risk of worsening motor symptoms. Thus, a balance must be struck between controlling nonmotor manifestations and motor features of the disease.
非运动症状是帕金森病（PD）的固有组成部分，它们比目前定义疾病的运动特征对残疾和生活质量的影响更大。PD 的非运动特征，如痴呆，可能是该疾病的固有特征，并且无论药物状态如何（即，它们在“开”或“关”状态下持续表现）；一些非运动特征，如精神病症状，可能是治疗 PD 运动症状的药物干预的医源性并发症。医源性并发症，如精神病和冲动控制障碍，可能需要通过修改 PD 治疗方案来治疗，但可能会恶化运动症状。因此，必须在控制疾病的非运动症状和运动特征之间取得平衡。
