Zhang Yanfeng, Liu Weiping, Xu Yang
Department of Dermatology, Tangshan Fengnan Hospital of Traditional Chinese Medicine, Tangshan, China.
Department of Dermatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Neurol. 2024 Dec 5;15:1471736. doi: 10.3389/fneur.2024.1471736. eCollection 2024.
This meta-analysis investigated the relationship between herpes zoster and the risk of dementia or Parkinson's disease by analyzing published clinical studies.
We systematically searched PubMed, Cochrane, Embase, and Web of Science Core Collection databases on April 25, 2024. Hazard ratios (HR) were used for statistical analyses. Random-effects models were applied, and heterogeneity was assessed using the I statistic.
Herpes zoster was associated with a non-significant trend toward increased dementia risk (HR = 1.11, 95% CI 0.99-1.24, = 0.07) but significantly increased Parkinson's disease risk (HR = 1.15, 95% CI 1.03-1.30, = 0.02). Subgroup analyses revealed that herpes zoster significantly elevated the risk of the prospective study subgroup (HR = 1.08, 95% CI 1.02-1.13, = 0.004) and vascular dementia subgroup (HR = 1.17, 95% CI 1.00-1.37, = 0.05). Significant heterogeneity was observed for both outcomes (dementia: = 98%, < 0.00001; Parkinson's disease: = 94%, < 0.00001).
Herpes zoster raises the risk of Parkinson's disease and vascular dementia, with a potential causal link to dementia. Early vaccination against herpes zoster is recommended over post-infection antiviral treatment to mitigate risks.
https://www.crd.york.ac.uk/PROSPERO/ and our registration number is CRD42024555620.
本荟萃分析通过分析已发表的临床研究，探讨带状疱疹与痴呆或帕金森病风险之间的关系。
我们于2024年4月25日系统检索了PubMed、Cochrane、Embase和Web of Science核心合集数据库。采用风险比（HR）进行统计分析。应用随机效应模型，并使用I统计量评估异质性。
带状疱疹与痴呆风险增加呈非显著趋势相关（HR = 1.11，95%置信区间0.99 - 1.24， = 0.07），但与帕金森病风险显著增加相关（HR = 1.15，95%置信区间1.03 - 1.30， = 0.02）。亚组分析显示，带状疱疹显著提高了前瞻性研究亚组（HR = 1.08，95%置信区间1.02 - 1.13， = 0.004）和血管性痴呆亚组（HR = 1.17，95%置信区间1.00 - 1.37， = 0.05）的风险。两种结果均观察到显著的异质性（痴呆： = 98%， < 0.00001；帕金森病： = 94%， < 0.00001）。
带状疱疹会增加帕金森病和血管性痴呆的风险，与痴呆可能存在因果联系。建议尽早接种带状疱疹疫苗，而非感染后进行抗病毒治疗，以降低风险。
https://www.crd.york.ac.uk/PROSPERO/ ，我们的注册号是CRD42024555620。
