系统性红斑狼疮患者外周血细胞上补体调节蛋白表达降低。
Diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients.
作者信息
Alegretti Ana Paula, Schneider Laiana, Piccoli Amanda Kirchner, Monticielo Odirlei Andre, Lora Priscila Schmidt, Brenol João Carlos Tavares, Xavier Ricardo Machado
机构信息
Serviço de Patologia Clínica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2° Andar, 90035-903 Porto Alegre, RS, Brazil.
出版信息
Clin Dev Immunol. 2012;2012:725684. doi: 10.1155/2012/725684. Epub 2012 Jun 12.
CD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated. The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disease activity. Flow cytometric analyses were performed on blood cells from 100 SLE patients and 61 healthy controls. Compared with healthy controls, we observed in SLE patients with lymphopenia and neutropenia decreased expression of CD55, CD59, and CD46 (P < 0.05). In SLE patients with anemia, CD59 and CD35 were decreased on red blood cells. Furthermore, there was a negative correlation between CD55 and CD59 on neutrophils and the disease activity. The results suggest there is an altered pattern of Creg expression on the peripheral blood cells of SLE patients, and the expression is correlated with disease activity and/or with activation of the complement system.
CD55、CD59、CD46和CD35是具有补体调节（Creg）特性的蛋白质，当该系统被激活时，它们可确保细胞和组织的完整性。本研究的目的是评估系统性红斑狼疮（SLE）患者外周血细胞上的Creg表达及其与血细胞减少和疾病活动的关系。对100例SLE患者和61例健康对照者的血细胞进行了流式细胞术分析。与健康对照相比，我们观察到淋巴细胞减少和中性粒细胞减少的SLE患者中CD55、CD59和CD46的表达降低（P<0.05）。在贫血的SLE患者中，红细胞上的CD59和CD35降低。此外，中性粒细胞上的CD55和CD59与疾病活动呈负相关。结果表明，SLE患者外周血细胞上的Creg表达模式发生改变，且该表达与疾病活动和/或补体系统的激活相关。
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